TY - JOUR
T1 - Optical coherence tomography characteristics of choroidal metastasis
AU - Arevalo, J. Fernando
AU - Fernandez, Carlos F.
AU - Garcia, Reinaldo A.
N1 - Funding Information:
Supported in part by the Fundación Arevalo-Coutinho para la Investigación en Oftalmología, Caracas, Venezuela (JFA, CFF, RAG), and the Pan-American Ophthalmological Foundation, Arlington, Texas (CFF).
PY - 2005/9
Y1 - 2005/9
N2 - Purpose: To report 4 patients (7 eyes) with choroidal metastasis (primary: breast [2], lung [1], and unknown [1]) visualized with optical coherence tomography (OCT). Design: Retrospective case series. Participants: Four patients (7 eyes) with choroidal metastasis participated in the study. Methods: Clinical examination, ultrasonography, fluorescein angiography, and OCT were performed in all cases. Main Outcome Measures: Optical coherence tomography characteristics. Results: Three patients suffered a gradual onset of blurred vision in both eyes. The fourth presented a unilateral decrease in visual acuity. Bilateral choroidal lesions with various degrees of exudative retinal detachment (RD) were present in 3 of our 4 patients, and there was 1 case of a unilateral unifocal choroidal lesion. Optical coherence tomography revealed anterior displacement of the photoreceptor layer by subretinal fluid (hyporeflective space) overlying a hyperreflective thickened retinal pigment epithelium-choriocapillaris complex. Subretinal deposits with several degrees of hyperreflectivity were seen, as well as loss of normal retinal architecture with intraretinal splitting, identified as regions of low reflectance within the neurosensory retina. After chemotherapy, OCT demonstrated improvement of the serous RD and reduction of the lesion's size with recovery of the normal retinal architecture. Conclusions: Optical coherence tomography in patients with choroidal metastasis allows evaluation of secondary retinal-retinal pigment epithelial changes. In addition, the technique is useful in the follow-up of lesions after treatment. However, some limitations result from the choroidal location of the metastasis. Further studies with clinicopathological correlation are needed to confirm our observations.
AB - Purpose: To report 4 patients (7 eyes) with choroidal metastasis (primary: breast [2], lung [1], and unknown [1]) visualized with optical coherence tomography (OCT). Design: Retrospective case series. Participants: Four patients (7 eyes) with choroidal metastasis participated in the study. Methods: Clinical examination, ultrasonography, fluorescein angiography, and OCT were performed in all cases. Main Outcome Measures: Optical coherence tomography characteristics. Results: Three patients suffered a gradual onset of blurred vision in both eyes. The fourth presented a unilateral decrease in visual acuity. Bilateral choroidal lesions with various degrees of exudative retinal detachment (RD) were present in 3 of our 4 patients, and there was 1 case of a unilateral unifocal choroidal lesion. Optical coherence tomography revealed anterior displacement of the photoreceptor layer by subretinal fluid (hyporeflective space) overlying a hyperreflective thickened retinal pigment epithelium-choriocapillaris complex. Subretinal deposits with several degrees of hyperreflectivity were seen, as well as loss of normal retinal architecture with intraretinal splitting, identified as regions of low reflectance within the neurosensory retina. After chemotherapy, OCT demonstrated improvement of the serous RD and reduction of the lesion's size with recovery of the normal retinal architecture. Conclusions: Optical coherence tomography in patients with choroidal metastasis allows evaluation of secondary retinal-retinal pigment epithelial changes. In addition, the technique is useful in the follow-up of lesions after treatment. However, some limitations result from the choroidal location of the metastasis. Further studies with clinicopathological correlation are needed to confirm our observations.
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U2 - 10.1016/j.ophtha.2005.03.030
DO - 10.1016/j.ophtha.2005.03.030
M3 - Article
C2 - 16039718
AN - SCOPUS:24944587261
SN - 0161-6420
VL - 112
SP - 1612
EP - 1619
JO - Ophthalmology
JF - Ophthalmology
IS - 9
ER -