TY - JOUR
T1 - Optical Coherence Tomography Angiography and en Face Optical Coherence Tomography Features of Paracentral Acute Middle Maculopathy
AU - Sridhar, Jayanth
AU - Shahlaee, Abtin
AU - Rahimy, Ehsan
AU - Hong, Bryan K.
AU - Khan, M. Ali
AU - Maguire, Joseph I.
AU - Dunn, James P.
AU - Mehta, Sonia
AU - Ho, Allen C.
N1 - Funding Information:
Funding/Support: No funding or grant support. A.C.H. has received research grant funding in the past from Alcon, Allergan, Avalanche, Genentech, Iconic, Janssen/Johnson & Johnson, NEI/NIH, Ophthotech, PanOptica, Regeneron, Second Sight, and Thrombogenics. Financial Disclosures: Joseph I. Maguire is a speaker for Regeneron and Genentech and on the advisory board for Genentech. Allen C. Ho is a scientific advisor for Aerpio, Alcon, Allergan, DigiSight, Beaver EndoOptiks, Janssen, Genentech, ONL, Ophthotech, Optovue, PanOptica, PRN, Regeneron, Second Sight, and Thrombogenics. Financial disclosures: The following authors have no financial disclosures: Jayanth Sridhar, Abtin Shahlaee, Ehsan Rahimy, Bryan K. Hong, M. Ali Khan, James P. Dunn, and Sonia Mehta. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Purpose To characterize the optical coherence tomography (OCT) angiography, en face OCT, and microperimetry features of paracentral acute middle maculopathy in both the acute phase and after resolution, and to propose a classification of distinct subtypes of this entity. Design Retrospective observational case series. Methods Clinical histories, high-resolution digital color imaging, spectral-domain OCT images, fluorescein angiography, OCT angiography images, and en face OCT images of 16 patients with paracentral acute middle maculopathy were evaluated. Microperimetry was available in 6 patients. Results The most common referring diagnoses were isolated branch retinal arterial occlusion (5/16), combined central retinal vein and cilioretinal artery occlusion (4/16), and isolated central retinal vein occlusion (4/16). All patients demonstrated hyperreflective plaque-like lesions at the level of the inner nuclear layer on spectral-domain OCT, with no fluorescein angiographic correlate. OCT angiography demonstrated variable areas of capillary dropout within the superficial and deep retinal capillary plexi in these areas. En face OCT highlighted confluent areas of middle retina hyperreflectivity corresponding to these lesions. Three distinct en face OCT patterns were observed: arteriolar, fern-like, and globular. Microperimetry demonstrated relative scotomas mapping to the area of middle retinal hyperreflectivity seen on en face OCT. Conclusions Paracentral acute middle maculopathy may be best evaluated with the use of en face OCT imaging, which corresponds to subjective and objective visual field defects. En face OCT appearance may be used to classify paracentral acute maculopathy into distinct subtypes.
AB - Purpose To characterize the optical coherence tomography (OCT) angiography, en face OCT, and microperimetry features of paracentral acute middle maculopathy in both the acute phase and after resolution, and to propose a classification of distinct subtypes of this entity. Design Retrospective observational case series. Methods Clinical histories, high-resolution digital color imaging, spectral-domain OCT images, fluorescein angiography, OCT angiography images, and en face OCT images of 16 patients with paracentral acute middle maculopathy were evaluated. Microperimetry was available in 6 patients. Results The most common referring diagnoses were isolated branch retinal arterial occlusion (5/16), combined central retinal vein and cilioretinal artery occlusion (4/16), and isolated central retinal vein occlusion (4/16). All patients demonstrated hyperreflective plaque-like lesions at the level of the inner nuclear layer on spectral-domain OCT, with no fluorescein angiographic correlate. OCT angiography demonstrated variable areas of capillary dropout within the superficial and deep retinal capillary plexi in these areas. En face OCT highlighted confluent areas of middle retina hyperreflectivity corresponding to these lesions. Three distinct en face OCT patterns were observed: arteriolar, fern-like, and globular. Microperimetry demonstrated relative scotomas mapping to the area of middle retinal hyperreflectivity seen on en face OCT. Conclusions Paracentral acute middle maculopathy may be best evaluated with the use of en face OCT imaging, which corresponds to subjective and objective visual field defects. En face OCT appearance may be used to classify paracentral acute maculopathy into distinct subtypes.
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U2 - 10.1016/j.ajo.2015.09.016
DO - 10.1016/j.ajo.2015.09.016
M3 - Article
C2 - 26386158
AN - SCOPUS:84960993514
SN - 0002-9394
VL - 160
SP - 1259-1268.e2
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -