Optical coherence microscopy in gastrointestinal tissues

Joseph A. Izatt, Hsing Wen Wang, Manish Kulkarni, Marcia I. Canto, Michael V. Sivak

Research output: Contribution to journalConference articlepeer-review


Optical coherence microscopy (OCM) is a novel technique complementary to optical coherence tomography (OCT), which combines low-coherence interferometry with confocal microscopy to achieve micron-resolution optical imaging deep in highly scattering media. This paper implements an OCM system specifically designed for high-resolution imaging deep in highly scattering tissues by utilizing low-coherence illumination from a superluminescent diode (SLD) source at 1.3-μm center wavelength. High-sensitivity detection of backscattered light (>95 dB dynamic range) is accomplished using heterodyne detection at 1.6-kHz modulation frequency, provided by small-amplitude PZT modulation of the reference arm length. Phase instabilities due to random thermal fluctuations in the fiber lengths are eliminated by digital demodulation of the interferometric signal at dual harmonics of the modulation frequency. Using a 0.65 N.A., 40× water-immersion objective, lateral and axial resolutions of 1.9 and 5 μm FWHM are obtained, respectively.

Original languageEnglish (US)
Pages (from-to)56-57
Number of pages2
JournalConference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS
StatePublished - Jan 1 1996
Externally publishedYes
EventProceedings of the 1996 Conference on Lasers and Electro-Optics, CLEO'96 - Anaheim, CA, USA
Duration: Jun 2 1996Jun 7 1996

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


Dive into the research topics of 'Optical coherence microscopy in gastrointestinal tissues'. Together they form a unique fingerprint.

Cite this