Optical coherence microscopy in gastrointestinal tissues

Joseph A. Izatt, Hsing Wen Wang, Manish Kulkarni, Marcia Canto, Michael V. Sivak

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Optical coherence microscopy (OCM) is a novel technique complementary to optical coherence tomography (OCT), which combines low-coherence interferometry with confocal microscopy to achieve micron-resolution optical imaging deep in highly scattering media. This paper implements an OCM system specifically designed for high-resolution imaging deep in highly scattering tissues by utilizing low-coherence illumination from a superluminescent diode (SLD) source at 1.3-μm center wavelength. High-sensitivity detection of backscattered light (>95 dB dynamic range) is accomplished using heterodyne detection at 1.6-kHz modulation frequency, provided by small-amplitude PZT modulation of the reference arm length. Phase instabilities due to random thermal fluctuations in the fiber lengths are eliminated by digital demodulation of the interferometric signal at dual harmonics of the modulation frequency. Using a 0.65 N.A., 40× water-immersion objective, lateral and axial resolutions of 1.9 and 5 μm FWHM are obtained, respectively.

Original languageEnglish (US)
Title of host publicationConference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS
PublisherIEEE
Pages56-57
Number of pages2
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 Conference on Lasers and Electro-Optics, CLEO'96 - Anaheim, CA, USA
Duration: Jun 2 1996Jun 7 1996

Other

OtherProceedings of the 1996 Conference on Lasers and Electro-Optics, CLEO'96
CityAnaheim, CA, USA
Period6/2/966/7/96

Fingerprint

Microscopic examination
Tissue
Frequency modulation
Scattering
Imaging techniques
Amplitude modulation
Confocal microscopy
Optical tomography
Demodulation
Full width at half maximum
Interferometry
Light sources
Diodes
Lighting
Wavelength
Fibers
Water

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Industrial and Manufacturing Engineering

Cite this

Izatt, J. A., Wang, H. W., Kulkarni, M., Canto, M., & Sivak, M. V. (1996). Optical coherence microscopy in gastrointestinal tissues. In Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS (pp. 56-57). IEEE.

Optical coherence microscopy in gastrointestinal tissues. / Izatt, Joseph A.; Wang, Hsing Wen; Kulkarni, Manish; Canto, Marcia; Sivak, Michael V.

Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. IEEE, 1996. p. 56-57.

Research output: Chapter in Book/Report/Conference proceedingChapter

Izatt, JA, Wang, HW, Kulkarni, M, Canto, M & Sivak, MV 1996, Optical coherence microscopy in gastrointestinal tissues. in Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. IEEE, pp. 56-57, Proceedings of the 1996 Conference on Lasers and Electro-Optics, CLEO'96, Anaheim, CA, USA, 6/2/96.
Izatt JA, Wang HW, Kulkarni M, Canto M, Sivak MV. Optical coherence microscopy in gastrointestinal tissues. In Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. IEEE. 1996. p. 56-57
Izatt, Joseph A. ; Wang, Hsing Wen ; Kulkarni, Manish ; Canto, Marcia ; Sivak, Michael V. / Optical coherence microscopy in gastrointestinal tissues. Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-LEOS. IEEE, 1996. pp. 56-57
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