Optic neuropathy from metastatic squamous cell carcinoma of the cervix: An unusual CNS presentation

Chia Chiao Portera, Rebecca F. Gottesman, Monica Srodon, Fariba Asrari, Michael Dillon, Deborah K. Armstrong

Research output: Contribution to journalArticlepeer-review

Abstract

Background.: Central nervous system (CNS) metastases from cervical carcinoma are uncommon events. Leptomeningeal involvement from cervical squamous cell carcinoma has not been extensively described. Case.: A 43-year-old woman with initial diagnosis of stage IB squamous cervical carcinoma at age 30 was treated with hysterectomy and left salpingo-oophorectomy. She recurred with nodal disease at age 39 and went into a clinical complete remission after chemotherapy and radiation treatment. Three years later, she presented with symptoms of optic neuropathy. Cerebral spinal fluid (CSF) was positive for squamous cells consistent with primary cervical squamous cell carcinoma. No measurable disease was evident outside of the CNS. Conclusion.: Meningeal carcinomatosis from cervical squamous cell carcinoma involving optic nerves has not been reported. Rapid progression of this patient's CNS metastatic disease suggests this form of metastases may be more aggressive and carry extremely poor prognosis.

Original languageEnglish (US)
Pages (from-to)121-123
Number of pages3
JournalGynecologic oncology
Volume102
Issue number1
DOIs
StatePublished - Jul 1 2006

Keywords

  • Cervical cancer
  • Meningeal carcinomatosis: central nervous system metastases
  • Optic neuropathy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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