Optic nerve protection, regeneration, and repair in the 21st century: LVIII Edward Jackson Memorial lecture

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Abstract

PURPOSE: To present the current status and clinical implications of optic nerve protection, repair, and regeneration after experimental injury in mammals, including nonhuman primates. DESIGN: Optic nerve and neuro-ophthalmology experimental study review. METHOD: Synthesis of experimental data regarding experimental studies of optic nerve protection, repair, and regeneration. RESULTS: Under certain conditions, mammalian retinal ganglion cells can be prevented from dying despite injury to the cell bodies or their axons, injured mammalian retinal ganglion cells whose axons have degenerated can be induced to extend new axons, and regenerating axons can reach their correct targets in the central nervous system. In addition, stem cells can be induced to become retinal ganglion cells. CONCLUSIONS: It may soon be possible to preserve and restore vision in persons whose sight is threatened or has been lost from disease or damage to the optic nerve.

Original languageEnglish (US)
Pages (from-to)811-818
Number of pages8
JournalAmerican journal of ophthalmology
Volume132
Issue number6
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Ophthalmology

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