Optic nerve head component responses of the multifocal electroretinogram in MS

Teresa C. Frohman, Shin Chien Beh, Shiv Saidha, Zane Schnurman, Darrel Conger, Amy Conger, John N. Ratchford, Carmen Lopez, Steven L. Galetta, Peter Calabresi, Laura J. Balcer, Ari J. Green, Elliot M. Frohman

Research output: Contribution to journalArticle

Abstract

Objective: To employ a novel stimulation paradigm in order to elicit multifocal electroretinography (mfERG)?induced optic nerve head component (ONHC) responses, believed to be contingent upon the transformation in electrical transmission properties of retinal ganglion cell axons from membrane to saltatory conduction mechanisms, as they traverse the lamina cribrosa and obtain oligodendrocyte myelin. We further sought to characterize abnormalities in ONHC responses in eyes from patients with multiple sclerosis (MS). Methods: In 10 normal subjects and 7 patients with MS (including eyes with and without a history of acute optic neuritis), we utilized a novel mfERG stimulation paradigm that included interleaved global flashes in order to elicit the ONHC responses from 103 retinal patches of pattern-reversal stimulation. Results: The number of abnormal or absent ONHC responses was significantly increased in MS patient eyes compared to normal subject eyes (p , 0.001, by general estimating equation modeling, and accounting for age and within-subject, intereye correlations). Conclusion: Studying the relationship between ONHC abnormalities and alterations in validated structural and functional measures of the visual system may facilitate the ability to dissect and characterize the pathobiological mechanisms that contribute to tissue damage in MS, and may have utility to detect and monitor neuroprotective or restorative effects of novel therapies.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalNeurology
Volume81
Issue number6
DOIs
StatePublished - Aug 6 2013

Fingerprint

Optic Disk
Multiple Sclerosis
Electroretinography
Optic Neuritis
Retinal Ganglion Cells
Oligodendroglia
Myelin Sheath
Axons
Cell Membrane
Optics
Nerve
Stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Frohman, T. C., Beh, S. C., Saidha, S., Schnurman, Z., Conger, D., Conger, A., ... Frohman, E. M. (2013). Optic nerve head component responses of the multifocal electroretinogram in MS. Neurology, 81(6), 545-551. https://doi.org/10.1212/WNL.0b013e31829e6faa

Optic nerve head component responses of the multifocal electroretinogram in MS. / Frohman, Teresa C.; Beh, Shin Chien; Saidha, Shiv; Schnurman, Zane; Conger, Darrel; Conger, Amy; Ratchford, John N.; Lopez, Carmen; Galetta, Steven L.; Calabresi, Peter; Balcer, Laura J.; Green, Ari J.; Frohman, Elliot M.

In: Neurology, Vol. 81, No. 6, 06.08.2013, p. 545-551.

Research output: Contribution to journalArticle

Frohman, TC, Beh, SC, Saidha, S, Schnurman, Z, Conger, D, Conger, A, Ratchford, JN, Lopez, C, Galetta, SL, Calabresi, P, Balcer, LJ, Green, AJ & Frohman, EM 2013, 'Optic nerve head component responses of the multifocal electroretinogram in MS', Neurology, vol. 81, no. 6, pp. 545-551. https://doi.org/10.1212/WNL.0b013e31829e6faa
Frohman, Teresa C. ; Beh, Shin Chien ; Saidha, Shiv ; Schnurman, Zane ; Conger, Darrel ; Conger, Amy ; Ratchford, John N. ; Lopez, Carmen ; Galetta, Steven L. ; Calabresi, Peter ; Balcer, Laura J. ; Green, Ari J. ; Frohman, Elliot M. / Optic nerve head component responses of the multifocal electroretinogram in MS. In: Neurology. 2013 ; Vol. 81, No. 6. pp. 545-551.
@article{9b2494350ab94330969f2a7eb12e45db,
title = "Optic nerve head component responses of the multifocal electroretinogram in MS",
abstract = "Objective: To employ a novel stimulation paradigm in order to elicit multifocal electroretinography (mfERG)?induced optic nerve head component (ONHC) responses, believed to be contingent upon the transformation in electrical transmission properties of retinal ganglion cell axons from membrane to saltatory conduction mechanisms, as they traverse the lamina cribrosa and obtain oligodendrocyte myelin. We further sought to characterize abnormalities in ONHC responses in eyes from patients with multiple sclerosis (MS). Methods: In 10 normal subjects and 7 patients with MS (including eyes with and without a history of acute optic neuritis), we utilized a novel mfERG stimulation paradigm that included interleaved global flashes in order to elicit the ONHC responses from 103 retinal patches of pattern-reversal stimulation. Results: The number of abnormal or absent ONHC responses was significantly increased in MS patient eyes compared to normal subject eyes (p , 0.001, by general estimating equation modeling, and accounting for age and within-subject, intereye correlations). Conclusion: Studying the relationship between ONHC abnormalities and alterations in validated structural and functional measures of the visual system may facilitate the ability to dissect and characterize the pathobiological mechanisms that contribute to tissue damage in MS, and may have utility to detect and monitor neuroprotective or restorative effects of novel therapies.",
author = "Frohman, {Teresa C.} and Beh, {Shin Chien} and Shiv Saidha and Zane Schnurman and Darrel Conger and Amy Conger and Ratchford, {John N.} and Carmen Lopez and Galetta, {Steven L.} and Peter Calabresi and Balcer, {Laura J.} and Green, {Ari J.} and Frohman, {Elliot M.}",
year = "2013",
month = "8",
day = "6",
doi = "10.1212/WNL.0b013e31829e6faa",
language = "English (US)",
volume = "81",
pages = "545--551",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Optic nerve head component responses of the multifocal electroretinogram in MS

AU - Frohman, Teresa C.

AU - Beh, Shin Chien

AU - Saidha, Shiv

AU - Schnurman, Zane

AU - Conger, Darrel

AU - Conger, Amy

AU - Ratchford, John N.

AU - Lopez, Carmen

AU - Galetta, Steven L.

AU - Calabresi, Peter

AU - Balcer, Laura J.

AU - Green, Ari J.

AU - Frohman, Elliot M.

PY - 2013/8/6

Y1 - 2013/8/6

N2 - Objective: To employ a novel stimulation paradigm in order to elicit multifocal electroretinography (mfERG)?induced optic nerve head component (ONHC) responses, believed to be contingent upon the transformation in electrical transmission properties of retinal ganglion cell axons from membrane to saltatory conduction mechanisms, as they traverse the lamina cribrosa and obtain oligodendrocyte myelin. We further sought to characterize abnormalities in ONHC responses in eyes from patients with multiple sclerosis (MS). Methods: In 10 normal subjects and 7 patients with MS (including eyes with and without a history of acute optic neuritis), we utilized a novel mfERG stimulation paradigm that included interleaved global flashes in order to elicit the ONHC responses from 103 retinal patches of pattern-reversal stimulation. Results: The number of abnormal or absent ONHC responses was significantly increased in MS patient eyes compared to normal subject eyes (p , 0.001, by general estimating equation modeling, and accounting for age and within-subject, intereye correlations). Conclusion: Studying the relationship between ONHC abnormalities and alterations in validated structural and functional measures of the visual system may facilitate the ability to dissect and characterize the pathobiological mechanisms that contribute to tissue damage in MS, and may have utility to detect and monitor neuroprotective or restorative effects of novel therapies.

AB - Objective: To employ a novel stimulation paradigm in order to elicit multifocal electroretinography (mfERG)?induced optic nerve head component (ONHC) responses, believed to be contingent upon the transformation in electrical transmission properties of retinal ganglion cell axons from membrane to saltatory conduction mechanisms, as they traverse the lamina cribrosa and obtain oligodendrocyte myelin. We further sought to characterize abnormalities in ONHC responses in eyes from patients with multiple sclerosis (MS). Methods: In 10 normal subjects and 7 patients with MS (including eyes with and without a history of acute optic neuritis), we utilized a novel mfERG stimulation paradigm that included interleaved global flashes in order to elicit the ONHC responses from 103 retinal patches of pattern-reversal stimulation. Results: The number of abnormal or absent ONHC responses was significantly increased in MS patient eyes compared to normal subject eyes (p , 0.001, by general estimating equation modeling, and accounting for age and within-subject, intereye correlations). Conclusion: Studying the relationship between ONHC abnormalities and alterations in validated structural and functional measures of the visual system may facilitate the ability to dissect and characterize the pathobiological mechanisms that contribute to tissue damage in MS, and may have utility to detect and monitor neuroprotective or restorative effects of novel therapies.

UR - http://www.scopus.com/inward/record.url?scp=84884548285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884548285&partnerID=8YFLogxK

U2 - 10.1212/WNL.0b013e31829e6faa

DO - 10.1212/WNL.0b013e31829e6faa

M3 - Article

VL - 81

SP - 545

EP - 551

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -