Optic Disc Edema after Bone Marrow Transplantation: Possible Role of Cyclosporine Toxicity

Robert Avery; Douglas A. Jabs; John R. Wingard; Georgia Vogelsang; Rein Saral; George Santos

doi:10.1016/S0161-6420(91)32140-7

Optic Disc Edema after Bone Marrow Transplantation: Possible Role of Cyclosporine Toxicity

Robert Avery, Douglas A. Jabs, John R. Wingard, Georgia Vogelsang, Rein Saral, George Santos

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Bone marrow transplantation has become widely used in the treatment of aplastic anemia and leukemia. Cyclosporine is used as prophylaxis against graft-versus-host disease. The authors report on eight cases of optic disc edema in patients taking cyclosporine after allogenic bone marrow transplant. Thorough evaluation revealed a possible alternate cause in two cases. In all cases, the optic disc edema resolved after discontinuing or decreasing the cyclosporine. Although cyclosporine has not previously been associated with optic disc edema, it has been implicated as the cause of a variety of neurologic side effects. Bone marrow transplant patients taking cyclosporine should be followed for the development of optic disc edema.

Original language	English (US)
Pages (from-to)	1294-1301
Number of pages	8
Journal	Ophthalmology
Volume	98
Issue number	8
DOIs	https://doi.org/10.1016/S0161-6420(91)32140-7
State	Published - 1991

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/S0161-6420(91)32140-7

Cite this

@article{fb01049b3b2b40e597ba15f7f25bd84b,

title = "Optic Disc Edema after Bone Marrow Transplantation: Possible Role of Cyclosporine Toxicity",

abstract = "Bone marrow transplantation has become widely used in the treatment of aplastic anemia and leukemia. Cyclosporine is used as prophylaxis against graft-versus-host disease. The authors report on eight cases of optic disc edema in patients taking cyclosporine after allogenic bone marrow transplant. Thorough evaluation revealed a possible alternate cause in two cases. In all cases, the optic disc edema resolved after discontinuing or decreasing the cyclosporine. Although cyclosporine has not previously been associated with optic disc edema, it has been implicated as the cause of a variety of neurologic side effects. Bone marrow transplant patients taking cyclosporine should be followed for the development of optic disc edema.",

author = "Robert Avery and Jabs, {Douglas A.} and Wingard, {John R.} and Georgia Vogelsang and Rein Saral and George Santos",

note = "Funding Information: Supported in part by NIH grant P01 CA 153960 from the National Cancer Institute/NIH, Bethesda, Maryland.",

year = "1991",

doi = "10.1016/S0161-6420(91)32140-7",

language = "English (US)",

volume = "98",

pages = "1294--1301",

journal = "Ophthalmology",

issn = "0161-6420",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Optic Disc Edema after Bone Marrow Transplantation

T2 - Possible Role of Cyclosporine Toxicity

AU - Avery, Robert

AU - Jabs, Douglas A.

AU - Wingard, John R.

AU - Vogelsang, Georgia

AU - Saral, Rein

AU - Santos, George

N1 - Funding Information: Supported in part by NIH grant P01 CA 153960 from the National Cancer Institute/NIH, Bethesda, Maryland.

PY - 1991

Y1 - 1991

N2 - Bone marrow transplantation has become widely used in the treatment of aplastic anemia and leukemia. Cyclosporine is used as prophylaxis against graft-versus-host disease. The authors report on eight cases of optic disc edema in patients taking cyclosporine after allogenic bone marrow transplant. Thorough evaluation revealed a possible alternate cause in two cases. In all cases, the optic disc edema resolved after discontinuing or decreasing the cyclosporine. Although cyclosporine has not previously been associated with optic disc edema, it has been implicated as the cause of a variety of neurologic side effects. Bone marrow transplant patients taking cyclosporine should be followed for the development of optic disc edema.

AB - Bone marrow transplantation has become widely used in the treatment of aplastic anemia and leukemia. Cyclosporine is used as prophylaxis against graft-versus-host disease. The authors report on eight cases of optic disc edema in patients taking cyclosporine after allogenic bone marrow transplant. Thorough evaluation revealed a possible alternate cause in two cases. In all cases, the optic disc edema resolved after discontinuing or decreasing the cyclosporine. Although cyclosporine has not previously been associated with optic disc edema, it has been implicated as the cause of a variety of neurologic side effects. Bone marrow transplant patients taking cyclosporine should be followed for the development of optic disc edema.

UR - http://www.scopus.com/inward/record.url?scp=0025944778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025944778&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(91)32140-7

DO - 10.1016/S0161-6420(91)32140-7

M3 - Article

C2 - 1923369

AN - SCOPUS:0025944778

SN - 0161-6420

VL - 98

SP - 1294

EP - 1301

JO - Ophthalmology

JF - Ophthalmology

IS - 8

ER -

Optic Disc Edema after Bone Marrow Transplantation: Possible Role of Cyclosporine Toxicity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this