Abstract
A 32-year-old woman with a history of biopsy-proven giant axonal neuropathy (GAN) and no past ocular history presented after failing a vision-screening test conducted by her primary doctor. Bilateral optic atrophy was observed on fundus examination with cup-to-disc ratio of 0.7. Kinetic visual fields showed moderate constriction in both eyes. Optical coherence tomography (OCT) of the retinal nerve fibre layer (RNFL) exhibited diffuse thinning, a pattern atypical of glaucomatous or nutritional optic atrophy and most likely secondary to the optic atrophy associated with GAN. Serial OCT to monitor RNFL thickness may offer a non-invasive means of monitoring progression in GAN for future therapeutic studies.
Original language | English (US) |
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Pages (from-to) | 209-213 |
Number of pages | 5 |
Journal | Neuro-Ophthalmology |
Volume | 37 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2013 |
Keywords
- Giant axonal neuropathy
- Non-glaucomatous cupping
- OCT
- Optic atrophy
- Retinal nerve fibre layer
ASJC Scopus subject areas
- Ophthalmology
- Clinical Neurology