Opposite effects of metallothionein I and spermine on mitochondrial function

Cuthbert O. Simpkins; Zhao H-Liao; Rahel Gebrehiwot; J. Adrian Tyndall; Cynthia A. Torrence; Tekum Fonong; Samuel Balderman; Eugene Mensah; Patricia M. Sokolove

doi:10.1016/0024-3205(96)00203-2

Opposite effects of metallothionein I and spermine on mitochondrial function

Cuthbert O. Simpkins, Zhao H-Liao, Rahel Gebrehiwot, J. Adrian Tyndall, Cynthia A. Torrence, Tekum Fonong, Samuel Balderman, Eugene Mensah, Patricia M. Sokolove

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO₂) of isolated rat liver mitochondria [Life Sci. 55 221-226, 1994]. We now present confirmation of this finding, and the additional observations that in rat liver mitochondria, MT caused swelling and depolarization. These actions of MT were inhibited by the aliphatic polyamine, spermine. Our findings suggest that mitochondrial function could be influenced by the balance between MT and spermine.

Original language	English (US)
Pages (from-to)	2091-2099
Number of pages	9
Journal	Life Sciences
Volume	58
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(96)00203-2
State	Published - May 3 1996

Keywords

Cyclosporine
Metallothionein
Mitochrondria
Spermine

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(96)00203-2

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Opposite effects of metallothionein I and spermine on mitochondrial function. / Simpkins, Cuthbert O.; H-Liao, Zhao; Gebrehiwot, Rahel; Tyndall, J. Adrian; Torrence, Cynthia A.; Fonong, Tekum; Balderman, Samuel; Mensah, Eugene; Sokolove, Patricia M.

In: Life Sciences, Vol. 58, No. 23, 03.05.1996, p. 2091-2099.

Research output: Contribution to journal › Article › peer-review

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AU - Torrence, Cynthia A.

AU - Fonong, Tekum

AU - Balderman, Samuel

AU - Mensah, Eugene

AU - Sokolove, Patricia M.

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AB - Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO2) of isolated rat liver mitochondria [Life Sci. 55 221-226, 1994]. We now present confirmation of this finding, and the additional observations that in rat liver mitochondria, MT caused swelling and depolarization. These actions of MT were inhibited by the aliphatic polyamine, spermine. Our findings suggest that mitochondrial function could be influenced by the balance between MT and spermine.

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KW - Mitochrondria

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