Opposite effects of metallothionein I and spermine on mitochondrial function

Cuthbert O. Simpkins, Zhao H-Liao, Rahel Gebrehiwot, J. Adrian Tyndall, Cynthia A. Torrence, Tekum Fonong, Samuel Balderman, Eugene Mensah, Patricia M. Sokolove

Research output: Contribution to journalArticle

Abstract

Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO2) of isolated rat liver mitochondria [Life Sci. 55 221-226, 1994]. We now present confirmation of this finding, and the additional observations that in rat liver mitochondria, MT caused swelling and depolarization. These actions of MT were inhibited by the aliphatic polyamine, spermine. Our findings suggest that mitochondrial function could be influenced by the balance between MT and spermine.

Original languageEnglish (US)
Pages (from-to)2091-2099
Number of pages9
JournalLife Sciences
Volume58
Issue number23
DOIs
StatePublished - May 3 1996
Externally publishedYes

Fingerprint

Spermine
Metallothionein
Mitochondria
Liver Mitochondrion
Liver
Rats
Depolarization
Polyamines
Heat-Shock Proteins
Oxygen Consumption
Swelling
Oxygen
Proteins

Keywords

  • Cyclosporine
  • Metallothionein
  • Mitochrondria
  • Spermine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Simpkins, C. O., H-Liao, Z., Gebrehiwot, R., Tyndall, J. A., Torrence, C. A., Fonong, T., ... Sokolove, P. M. (1996). Opposite effects of metallothionein I and spermine on mitochondrial function. Life Sciences, 58(23), 2091-2099. https://doi.org/10.1016/0024-3205(96)00203-2

Opposite effects of metallothionein I and spermine on mitochondrial function. / Simpkins, Cuthbert O.; H-Liao, Zhao; Gebrehiwot, Rahel; Tyndall, J. Adrian; Torrence, Cynthia A.; Fonong, Tekum; Balderman, Samuel; Mensah, Eugene; Sokolove, Patricia M.

In: Life Sciences, Vol. 58, No. 23, 03.05.1996, p. 2091-2099.

Research output: Contribution to journalArticle

Simpkins, CO, H-Liao, Z, Gebrehiwot, R, Tyndall, JA, Torrence, CA, Fonong, T, Balderman, S, Mensah, E & Sokolove, PM 1996, 'Opposite effects of metallothionein I and spermine on mitochondrial function', Life Sciences, vol. 58, no. 23, pp. 2091-2099. https://doi.org/10.1016/0024-3205(96)00203-2
Simpkins CO, H-Liao Z, Gebrehiwot R, Tyndall JA, Torrence CA, Fonong T et al. Opposite effects of metallothionein I and spermine on mitochondrial function. Life Sciences. 1996 May 3;58(23):2091-2099. https://doi.org/10.1016/0024-3205(96)00203-2
Simpkins, Cuthbert O. ; H-Liao, Zhao ; Gebrehiwot, Rahel ; Tyndall, J. Adrian ; Torrence, Cynthia A. ; Fonong, Tekum ; Balderman, Samuel ; Mensah, Eugene ; Sokolove, Patricia M. / Opposite effects of metallothionein I and spermine on mitochondrial function. In: Life Sciences. 1996 ; Vol. 58, No. 23. pp. 2091-2099.
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