Opposite effects of metallothionein I and spermine on mitochondrial function

Cuthbert O. Simpkins, Zhao H-Liao, Rahel Gebrehiwot, J. Adrian Tyndall, Cynthia A. Torrence, Tekum Fonong, Samuel Balderman, Eugene Mensah, Patricia M. Sokolove

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO2) of isolated rat liver mitochondria [Life Sci. 55 221-226, 1994]. We now present confirmation of this finding, and the additional observations that in rat liver mitochondria, MT caused swelling and depolarization. These actions of MT were inhibited by the aliphatic polyamine, spermine. Our findings suggest that mitochondrial function could be influenced by the balance between MT and spermine.

Original languageEnglish (US)
Pages (from-to)2091-2099
Number of pages9
JournalLife Sciences
Issue number23
StatePublished - May 3 1996


  • Cyclosporine
  • Metallothionein
  • Mitochrondria
  • Spermine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'Opposite effects of metallothionein I and spermine on mitochondrial function'. Together they form a unique fingerprint.

Cite this