Opposite effects of metallothionein I and spermine on mitochondrial function

Cuthbert O. Simpkins, Zhao H-Liao, Rahel Gebrehiwot, J. Adrian Tyndall, Cynthia A. Torrence, Tekum Fonong, Samuel Balderman, Eugene Mensah, Patricia M. Sokolove

Research output: Contribution to journalArticlepeer-review

Abstract

Previously, we reported that the stress-induced protein metallothionein I (MT) modulated the oxygen consumption (VO2) of isolated rat liver mitochondria [Life Sci. 55 221-226, 1994]. We now present confirmation of this finding, and the additional observations that in rat liver mitochondria, MT caused swelling and depolarization. These actions of MT were inhibited by the aliphatic polyamine, spermine. Our findings suggest that mitochondrial function could be influenced by the balance between MT and spermine.

Original languageEnglish (US)
Pages (from-to)2091-2099
Number of pages9
JournalLife Sciences
Volume58
Issue number23
DOIs
StatePublished - May 3 1996

Keywords

  • Cyclosporine
  • Metallothionein
  • Mitochrondria
  • Spermine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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