Opportunities in precision psychiatry using PET neuroimaging in psychosis

Research output: Contribution to journalReview articlepeer-review

Abstract

With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

Original languageEnglish (US)
Article number104428
JournalNeurobiology of Disease
Volume131
DOIs
StatePublished - Nov 2019

Keywords

  • Dopamine
  • Neuroimmunity
  • PET imaging
  • Precision medicine
  • Psychosis
  • alpha7 nicotinic acetylcholine receptor

ASJC Scopus subject areas

  • Neurology

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