Opportunities in precision psychiatry using PET neuroimaging in psychosis

Research output: Contribution to journalReview article

Abstract

With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

Original languageEnglish (US)
JournalNeurobiology of Disease
DOIs
StatePublished - Jan 1 2019

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Neuroimaging
Positron-Emission Tomography
Psychotic Disorders
Psychiatry
Precision Medicine
Molecular Imaging
Therapeutics
Biomarkers
Delivery of Health Care

Keywords

  • alpha7 nicotinic acetylcholine receptor
  • Dopamine
  • Neuroimmunity
  • PET imaging
  • Precision medicine
  • Psychosis

ASJC Scopus subject areas

  • Neurology

Cite this

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title = "Opportunities in precision psychiatry using PET neuroimaging in psychosis",
abstract = "With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.",
keywords = "alpha7 nicotinic acetylcholine receptor, Dopamine, Neuroimmunity, PET imaging, Precision medicine, Psychosis",
author = "Coughlin, {Jennifer Marie} and Andrew Horti and Pomper, {Martin Gilbert}",
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AB - With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that guide subtype-specific therapeutic interventions. This review presents selected PET findings that exemplify early promise in using molecular imaging to predict treatment response, provide rationale for new therapeutic targets, and monitor target engagement in biomarker-defined subtypes of psychosis. PET data, among other data types, may prove useful in the scientific pursuit of identifying precision strategies to improve clinical outcomes for individuals with psychosis.

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