Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers

Perry V. Halushka, Andrew J. Goodwin, Marc K Halushka

Research output: Contribution to journalReview article

Abstract

Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in afflicted individuals. microRNAs are small regulatory RNAs that modulate translation and have been identified as potential fluid-based biomarkers across numerous maladies. We describe the current state of cardiovascular disease biomarkers across a range of diseases, including myocardial infarction, acute coronary syndrome, myocarditis, hypertension, heart failure, heart transplantation, aortic stenosis, diabetic cardiomyopathy, atrial fibrillation, and sepsis. We present the current understanding of microRNAs as possible biomarkers in these categories and where their best opportunities exist to enter clinical practice.

Original languageEnglish (US)
Pages (from-to)211-238
Number of pages28
JournalAnnual Review of Pathology: Mechanisms of Disease
Volume14
DOIs
StatePublished - Jan 1 2019

Keywords

  • microRNAs, biomarkers, cardiovascular disease, hypertension, sepsis, aortic stenosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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