Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment

Alexandra V. Lucs, Benjamin Saltman, Christine H. Chung, Bettie M. Steinberg, David L. Schwartz

Research output: Contribution to journalArticle

Abstract

Head and neck oncologists have traditionally relied on clinical tumor features and patient characteristics to guide care of individual patients. As surgical, radiotherapeutic, and systemic treatments have evolved to become more anatomically precise and mechanistically specific, the opportunity for improved cure and functional patient recovery has never been more promising for this historically debilitating cancer. However, personalized treatment must be accompanied by sophisticated patient selection to triage the application of advanced therapies toward ideal patient candidates. In this monograph, we review current progress, investigative themes, and key challenges facing head and neck cancer biomarker development intended to make personalized head and neck cancer treatment a clinical reality.

Original languageEnglish (US)
Pages (from-to)294-306
Number of pages13
JournalHead and Neck
Volume35
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • biomarker
  • DNA damage repair
  • epidermal growth factor receptor
  • functional imaging
  • head and neck cancer
  • human papillomavirus
  • magnetic resonance imaging
  • microarray
  • noncoding RNA
  • personalized therapy
  • positron-emission tomography
  • prognosis
  • radiotherapy
  • treatment response

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Lucs, A. V., Saltman, B., Chung, C. H., Steinberg, B. M., & Schwartz, D. L. (2013). Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment. Head and Neck, 35(2), 294-306. https://doi.org/10.1002/hed.21975