Opioids: Similarity between evaluations of subjective effects and animal self-administration results

Roland R Griffiths, Robert L. Balster

Research output: Contribution to journalArticle

Abstract

Abuse potential studies of 33 morphine-like analgesics were compared in humans and monkeys. The results of intravenous self-administration studies in rhesus monkeys were correlated with measures of morphine-like signs, symptoms, and subjective effects in ex-addicts. Each set of data was assigned to a position in a 3 × 3 contingency table dependent upon whether the results were yes, no, or equivocal. Of the 33 drugs, 29 were given identical classifications in both the human and animal test procedures. This good concordance between the human and animal results further validates each procedure and suggests the possibility that both the human and animal procedures are measuring a common underlying pharmacological property which relates to abuse potential of drugs.

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume25
Issue number5 PART 1
StatePublished - May 1979

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Self Administration
Opioid Analgesics
Morphine
Macaca mulatta
Intravenous Administration
Signs and Symptoms
Substance-Related Disorders
Haplorhini
Analgesics
Pharmacology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Opioids : Similarity between evaluations of subjective effects and animal self-administration results. / Griffiths, Roland R; Balster, Robert L.

In: Clinical Pharmacology and Therapeutics, Vol. 25, No. 5 PART 1, 05.1979, p. 611-617.

Research output: Contribution to journalArticle

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