This chapter presents a concise overview of the pharmacology, clinical uses, and adverse effects of morphine-like drugs ('opioids'). Morphine, a natural product whose beneficial therapeutic use was discovered serendipitously thousands of years ago, remains the =gold standard' for the relief of moderate to severe pain. Following the elucidation of morphine's chemical structure at the beginning of the 19th century and subsequent extensive design, synthesis, and testing of chemical analogs by pharmaceutical and academic laboratories, today there are multiple opioids available to the clinician. Although each is morphine-like and shares certain fundamental characteristics with morphine, they each have particular features, the nuances of which influence their clinical use and usefulness.
|Original language||English (US)|
|Title of host publication||Opioids: Pharmacology, Clinical Uses and Adverse Effects|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||19|
|State||Published - 2012|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)