Opioids: Pharmacology, clinical uses and adverse effects

Robert Taylor, Joseph V. Pergolizzi, Robert B. Raffa, Edmundo Muniz

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter presents a concise overview of the pharmacology, clinical uses, and adverse effects of morphine-like drugs ('opioids'). Morphine, a natural product whose beneficial therapeutic use was discovered serendipitously thousands of years ago, remains the =gold standard' for the relief of moderate to severe pain. Following the elucidation of morphine's chemical structure at the beginning of the 19th century and subsequent extensive design, synthesis, and testing of chemical analogs by pharmaceutical and academic laboratories, today there are multiple opioids available to the clinician. Although each is morphine-like and shares certain fundamental characteristics with morphine, they each have particular features, the nuances of which influence their clinical use and usefulness.

Original languageEnglish (US)
Title of host publicationOpioids: Pharmacology, Clinical Uses and Adverse Effects
PublisherNova Science Publishers, Inc.
Pages75-93
Number of pages19
ISBN (Print)9781619421011
StatePublished - 2012

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Taylor, R., Pergolizzi, J. V., Raffa, R. B., & Muniz, E. (2012). Opioids: Pharmacology, clinical uses and adverse effects. In Opioids: Pharmacology, Clinical Uses and Adverse Effects (pp. 75-93). Nova Science Publishers, Inc..