Opioid peptide enkephalin

immunohistochemical mapping in rat central nervous system

R. Simantov, M. J. Kuhar, G. R. Uhi, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Using specific antisera to methionine-enkephalin and leucine-enkephalin, apparent enkephalin-containing neuronal fibers and terminals throughout the central nervous system of the rat were visualized. Immunoreactive enkephalin displays sharply defined localizations. Regions of highest immunofluorescent density include the laminae I and II of the spinal cord, the substantia gelatinosa of the caudal nucleus of nerve V, the vagal nuclei of the medulla, the periventricular and periaqueductal areas of the upper medulla and midbrain, dorsomedial thalamic regions, specific hypothalamic nuclei, the basal ganglia, particularly the globus pallidus and the central nucleus of the amygdala, and the lateral septum. In certain regions enkephalin immunofluorescence corresponds closely with the distribution of autoradiographic opiate receptor grains.

Original languageEnglish (US)
Pages (from-to)2167-2171
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number5
StatePublished - 1977

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Opioid Peptides
Enkephalins
Substantia Gelatinosa
Central Nervous System
Leucine Enkephalin
Methionine Enkephalin
Trigeminal Nerve
Globus Pallidus
Opioid Receptors
Mesencephalon
Basal Ganglia
Fluorescent Antibody Technique
Immune Sera
Spinal Cord

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Opioid peptide enkephalin : immunohistochemical mapping in rat central nervous system. / Simantov, R.; Kuhar, M. J.; Uhi, G. R.; Snyder, Solomon H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 75, No. 5, 1977, p. 2167-2171.

Research output: Contribution to journalArticle

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