Abstract
Aims: To examine the relationship of anxiety and depression symptoms with treatment outcomes (treatment discontinuation, rates of ongoing use of illicit drugs and likelihood of preterm delivery) in opioid-dependent pregnant women and describe their use of psychotropic medications. Design and setting: Secondary data analysis from a randomized clinical trial of treatment for opioid dependence during pregnancy. Participants: A total of 175 opioid-dependent pregnant women, of whom 131 completed treatment. Measurements: Symptoms of anxiety and depression were captured with the 15-item Mini International Neuropsychiatric Interview (MINI) screen. Use of illicit drugs was measured by urine drug screening. Preterm delivery was defined as delivery prior to 37 weeks' gestation. Self-reported use of concomitant psychotropic medication at any point during the study was recorded. Findings: Women reporting only anxiety symptoms at study entry were more likely to discontinue treatment [adjusted odds ratio (OR)=4.56, 95% confidence interval (CI):1.91-13.26, P=0.012], while those reporting only depression symptoms were less likely to discontinue treatment (adjusted OR=0.14, 95% CI:0.20-0.88, P=0.036) compared to women who reported neither depression nor anxiety symptoms. No statistically significant between-group differences were observed for ongoing illicit drug use or preterm delivery. A majority (61.4%) of women reported use of concomitant psychotropic medication at some point during study participation. Conclusions: Opioid agonist-treated pregnant patients with co-occurring symptoms of anxiety require additional clinical resources to prevent premature discontinuation.
Original language | English (US) |
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Pages (from-to) | 74-82 |
Number of pages | 9 |
Journal | Addiction |
Volume | 107 |
Issue number | SUPPL.1 |
DOIs | |
State | Published - Nov 2012 |
Externally published | Yes |
Keywords
- Anxiety
- Buprenorphine
- Depression
- Methadone
- Opioid-dependence
- Outcomes
- Pregnancy
- Treatment-retention
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Psychiatry and Mental health