TY - JOUR
T1 - Opiate receptor
T2 - Autoradiographic localization in rat brain
AU - Pert, C. B.
AU - Kuhar, M. J.
AU - Snyder, S. H.
PY - 1976
Y1 - 1976
N2 - Opiate receptor sites in rat brain can be labeled in vivo by [3H]diprenorphine, a potent opiate antagonist. Using techniques to minimize diffusion in fresh, frozen, unfixed brain, we have localized [3H]diprenorphine by autoradiography to visualize the distribution of opiate receptors. Silver grains indicative of the binding of labeled [3H]diprenorphine are discretely localized in numerous areas of the brain with very high densities in the locus coeruleus, the substantia gelatinosa of the spinal cord, and in clusters within the caudate putamen, amygdala, and parts of the periventricular gray matter.
AB - Opiate receptor sites in rat brain can be labeled in vivo by [3H]diprenorphine, a potent opiate antagonist. Using techniques to minimize diffusion in fresh, frozen, unfixed brain, we have localized [3H]diprenorphine by autoradiography to visualize the distribution of opiate receptors. Silver grains indicative of the binding of labeled [3H]diprenorphine are discretely localized in numerous areas of the brain with very high densities in the locus coeruleus, the substantia gelatinosa of the spinal cord, and in clusters within the caudate putamen, amygdala, and parts of the periventricular gray matter.
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U2 - 10.1073/pnas.73.10.3729
DO - 10.1073/pnas.73.10.3729
M3 - Article
C2 - 185626
AN - SCOPUS:0013659375
SN - 0027-8424
VL - 73
SP - 3729
EP - 3733
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -