Opiate antagonists improve spatial memory

Michela Gallagher; Richard A. King; Nancy B. Young

doi:10.1126/science.6879198

Opiate antagonists improve spatial memory

Michela Gallagher, Richard A. King, Nancy B. Young

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.

Original language	English (US)
Pages (from-to)	975-976
Number of pages	2
Journal	Science
Volume	221
Issue number	4614
DOIs	https://doi.org/10.1126/science.6879198
State	Published - 1983
Externally published	Yes

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title = "Opiate antagonists improve spatial memory",

abstract = "Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.",

author = "Michela Gallagher and King, {Richard A.} and Young, {Nancy B.}",

year = "1983",

doi = "10.1126/science.6879198",

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AU - Young, Nancy B.

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AB - Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.

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Opiate antagonists improve spatial memory

Abstract

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