Opiate antagonists improve spatial memory

Michela Gallagher, Richard A. King, Nancy B. Young

Research output: Contribution to journalArticlepeer-review

Abstract

Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.

Original languageEnglish (US)
Pages (from-to)975-976
Number of pages2
JournalScience
Volume221
Issue number4614
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

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