Abstract
Purpose: To better describe the clinical and neuroimaging spectrum of abnormalities in clinical anophthalmos. Methods: We performed a retrospective review of all 17 patients admitted to the King Khaled Eye Specialist Hospital with clinical anophthalmos over a 15 year period who had a complete ophthalmological examination documented and received computed tomographic (CT) imaging of the orbits and brain. Results: Patients with clinical anophthalmos had a high incidence of developmental abnormalities involving both eyes (15/17 patients, 88%), the brain (12/17 patients, 71%) and the body (7/12, 58%). The incidence of central nervous system anomalies reached 100% in patients with bilateral small optic nerves on CT scan. Conclusions: Patients with clinical anophthalmos share a similar constellation of neurological, somatic and neuroradiological abnormalities as patients with microphthalmos, septo-optic dysplasia and clinical optic nerve hypoplasia. This fact may provide insight into developmental abnormalities of the afferent visual system and brain.
Original language | English (US) |
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Pages (from-to) | 82-87 |
Number of pages | 6 |
Journal | Eye |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2000 |
Externally published | Yes |
Keywords
- Anophthalmos
- Coloboma
- Developmental anomaly
- Dysgenesis
- Microphthalmos
- Optic nerve hypoplasia
- Septo-optic dysplasia
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems