TY - JOUR
T1 - Ophthalmologic Manifestations of Sickle Cell Thalassemia
AU - Goldberg, Morton F.
AU - Charache, Samuel
AU - Acacio, Ireneo
PY - 1971/7
Y1 - 1971/7
N2 - Vascular abnormalities were studied in the eyes of 14 patients with sickle cell thalassemia (S-thal). Angioid streaks were observed for the first time in a patient with S-thal. “Black sunbursts,” which are seen more often in the fundi of patients with sickle cell anemia (SS disease) than in those with sickle cell hemoglobin C disease (Hb SC) were generally few in number in the fundi of patients with S-thal. Proliferative sickle retinopathy, which is much more characteristic of Hb SC than of SS disease, was seen in nine patients with S-thal. The retinas of S-thal thus resemble those of Hb SC more than SS. The hemoglobin composition of a patient's red blood cells can be predicted, to a degree, from the presence and type of certain retinal anomalies in sickling disorders. Overall clinical status is not usually as good as indicator of hemoglobin composition.
AB - Vascular abnormalities were studied in the eyes of 14 patients with sickle cell thalassemia (S-thal). Angioid streaks were observed for the first time in a patient with S-thal. “Black sunbursts,” which are seen more often in the fundi of patients with sickle cell anemia (SS disease) than in those with sickle cell hemoglobin C disease (Hb SC) were generally few in number in the fundi of patients with S-thal. Proliferative sickle retinopathy, which is much more characteristic of Hb SC than of SS disease, was seen in nine patients with S-thal. The retinas of S-thal thus resemble those of Hb SC more than SS. The hemoglobin composition of a patient's red blood cells can be predicted, to a degree, from the presence and type of certain retinal anomalies in sickling disorders. Overall clinical status is not usually as good as indicator of hemoglobin composition.
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U2 - 10.1001/archinte.1971.00310190037002
DO - 10.1001/archinte.1971.00310190037002
M3 - Article
C2 - 5088411
AN - SCOPUS:0015099168
SN - 0003-9926
VL - 128
SP - 33
EP - 39
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 1
ER -