Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon

Michael R. Narkewicz, Philip Rosenthal, Kathleen Schwarz, Arlene Drack, Todd Margolis, Michael X Repka

Research output: Contribution to journalArticle

Abstract

Objectives: Interferon treatment for chronic viral hepatitis C (HCV) has been associated with the development of retinopathy in 19% to 29% of adults. Our purpose is to describe the ophthalmologic complications of pegylated interferon-α2a with either placebo or ribavirin in children with chronic HCV (the PEDS-C trial). Materials and Methods: Prospective, comprehensive ophthalmologic examinations including slit lamp at enrollment and after 24 and 48 weeks of treatment of 114 children participating in a randomized clinical trial. Results: One hundred and twenty-eight children were screened for entry, of whom 123 had an eye examination and no child had existing retinal disease. One hundred fourteen children were eligible and were treated. One hundred ten children had an eye examination at 24 weeks and 103 children at 48 weeks. Three of 114 subjects (2.6%) developed documented (n = 2) or possible (1) serious eye complications. One subject developed evidence of ischemic retinopathy (cotton-wool spots) by week 24, 1 developed uveitis by week 48, and 1 reported at week 48 transient (

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume51
Issue number2
DOIs
StatePublished - Aug 2010

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Chronic Hepatitis C
Interferons
Retinal Diseases
Wool
Ribavirin
Uveitis
Randomized Controlled Trials
Placebos
Therapeutics

Keywords

  • hepatitis C
  • interferon
  • retinopathy

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon. / Narkewicz, Michael R.; Rosenthal, Philip; Schwarz, Kathleen; Drack, Arlene; Margolis, Todd; Repka, Michael X.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 51, No. 2, 08.2010, p. 183-186.

Research output: Contribution to journalArticle

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