Ophthalmlic Involvement in Aggressive Histiocytosis X

Mathew W. MacCumber, Paul N. Hoffman, Gary S. Wand, Jonathan I. Epstein, William E. Beschorner, W. Richard Green

Research output: Contribution to journalArticlepeer-review

Abstract

The authors report the clinicopathologic features of an unusually aggressive form of histiocytosis X (Langerhans' cell histiocytosis) in a 36-yearold man who presented with diplopia and early development of pituitary failure from presumed involvement of the hypothalamus. Results of postmortem examination showed infiltrates of histiocytes and mixed inflammatory cells, with a variably dense desmoplastic tissue within the orbit and sclera bilaterally, the left optic nerve, choroid, emissary canals, and many other body systems including the pituitary, heart, lung, and gastrointestinal tract. Diagnosis was confirmed by immunohistochemical staining of large histiocytes within diseased areas, with anti-T6 and anti-S-100 antibodies.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalOphthalmology
Volume97
Issue number1
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Ophthalmlic Involvement in Aggressive Histiocytosis X'. Together they form a unique fingerprint.

Cite this