Ophthalmic manifestations of neonatal onset multisystem inflammatory disease

Irene C Kuo, Joseph Fan, Emmett T. Cunningham

Research output: Contribution to journalArticle

Abstract

PURPOSE: To report the ophthalmic manifestations of neonatal onset multisystem inflammatory disease, a recently recognized, rare systemic disorder characterized by the triad of arthropathy, rash, and abnormal central nervous system development. METHOD: Case report. RESULTS: A 2-year-old female with neonatal onset multisystem inflammatory disease presented with visual acuity of fix and follow with each eye, bilateral optic nerve head pallor and gliosis, as well as marked sheathing of the peripapillary vessels. No vitreous inflammation or macular edema was found. Visual acuity was stable from the neonatal period through the 3 months of follow-up after the changes involving the optic nerve heads and peripapillary vessels were observed (a total of 33 months). CONCLUSIONS: This report provides a description of the ocular manifestations of neonatal onset multisystem inflammatory disease and supports earlier suggestions that swelling of the optic nerve heads can occur. In this case, optic nerve head pallor may have been a sequela of such swelling. The pathogenesis of neonatal onset multisystem inflammatory disease is unknown. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)856-858
Number of pages3
JournalAmerican Journal of Ophthalmology
Volume130
Issue number6
DOIs
StatePublished - 2000

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Eye Manifestations
Cryopyrin-Associated Periodic Syndromes
Optic Disk
Pallor
Visual Acuity
Gliosis
Macular Edema
Joint Diseases
Exanthema
varespladib methyl
Central Nervous System
Inflammation

ASJC Scopus subject areas

  • Ophthalmology

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Ophthalmic manifestations of neonatal onset multisystem inflammatory disease. / Kuo, Irene C; Fan, Joseph; Cunningham, Emmett T.

In: American Journal of Ophthalmology, Vol. 130, No. 6, 2000, p. 856-858.

Research output: Contribution to journalArticle

Kuo, Irene C ; Fan, Joseph ; Cunningham, Emmett T. / Ophthalmic manifestations of neonatal onset multisystem inflammatory disease. In: American Journal of Ophthalmology. 2000 ; Vol. 130, No. 6. pp. 856-858.
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