Ophthalmic involvement in aggressive histiocytosis X

M. W. MacCumber, P. N. Hoffman, Gary S Wand, Jonathan Ira Epstein, W. E. Beschorner, W. R. Green

Research output: Contribution to journalArticle


The authors report the clinicopathologic features of an unusually aggressive form of histiocytosis X (Langerhans' cell histiocytosis) in a 36-year-old man who presented with diplopia and early development of pituitary failure from presumed involvement of the hypothalamus. Results of postmortem examination showed infiltrates of histiocytes and mixed inflammatory cells, with a variably dense desmoplastic tissue within the orbit and sclera bilaterally, the left optic nerve, choroid, emissary canals, and many other body systems including the pituitary, heart, lung, and gastrointestinal tract. Diagnosis swas confirmed by immunohistochemical staining of large histiocytes within diseased areas, with anti-T6 and anti-S-100 antibodies.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
Issue number1
StatePublished - 1990


ASJC Scopus subject areas

  • Ophthalmology

Cite this

MacCumber, M. W., Hoffman, P. N., Wand, G. S., Epstein, J. I., Beschorner, W. E., & Green, W. R. (1990). Ophthalmic involvement in aggressive histiocytosis X. Ophthalmology, 97(1), 22-27.