Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1

Richard Mayeux; Christiane Reitz; Adam M. Brickman; Mary N. Haan; Jennifer J. Manly; M. Maria Glymour; Christopher C. Weiss; Kristine Yaffe; Laura Middleton; Hugh C. Hendrie; Lauren H. Warren; Kathleen M. Hayden; Kathleen A. Welsh-Bohmer; John C.S. Breitner; John C. Morris

doi:10.1016/j.jalz.2010.11.005

Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1

Richard Mayeux, Christiane Reitz, Adam M. Brickman, Mary N. Haan, Jennifer J. Manly, M. Maria Glymour, Christopher C. Weiss, Kristine Yaffe, Laura Middleton, Hugh C. Hendrie, Lauren H. Warren, Kathleen M. Hayden, Kathleen A. Welsh-Bohmer, John C.S. Breitner, John C. Morris

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia".

Original language	English (US)
Pages (from-to)	15-34
Number of pages	20
Journal	Alzheimer's and Dementia
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2010.11.005
State	Published - Jan 2011
Externally published	Yes

Keywords

Alzheimer's disease
Cognitive impairment
Dementia
Diagnostic criteria

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

Access to Document

10.1016/j.jalz.2010.11.005

Cite this

Mayeux, R., Reitz, C., Brickman, A. M., Haan, M. N., Manly, J. J., Glymour, M. M., Weiss, C. C., Yaffe, K., Middleton, L., Hendrie, H. C., Warren, L. H., Hayden, K. M., Welsh-Bohmer, K. A., Breitner, J. C. S., & Morris, J. C. (2011). Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1. Alzheimer's and Dementia, 7(1), 15-34. https://doi.org/10.1016/j.jalz.2010.11.005

Mayeux, R, Reitz, C, Brickman, AM, Haan, MN, Manly, JJ, Glymour, MM, Weiss, CC, Yaffe, K, Middleton, L, Hendrie, HC, Warren, LH, Hayden, KM, Welsh-Bohmer, KA, Breitner, JCS & Morris, JC 2011, 'Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1', Alzheimer's and Dementia, vol. 7, no. 1, pp. 15-34. https://doi.org/10.1016/j.jalz.2010.11.005

@article{4be566917eec4ba5a1a2550d26c3b016,

title = "Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1",

abstract = "In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in {"}mixed dementia{"}.",

keywords = "Alzheimer's disease, Cognitive impairment, Dementia, Diagnostic criteria",

author = "Richard Mayeux and Christiane Reitz and Brickman, {Adam M.} and Haan, {Mary N.} and Manly, {Jennifer J.} and Glymour, {M. Maria} and Weiss, {Christopher C.} and Kristine Yaffe and Laura Middleton and Hendrie, {Hugh C.} and Warren, {Lauren H.} and Hayden, {Kathleen M.} and Welsh-Bohmer, {Kathleen A.} and Breitner, {John C.S.} and Morris, {John C.}",

note = "Funding Information: This combined effort was supported by National Institute on Aging grants P01AG007232, R01AG012975, R01AG016206, R01AG009956, R01AG011380, P30AG028377, P50AG05681, and K01AG029336 . ",

year = "2011",

month = jan,

doi = "10.1016/j.jalz.2010.11.005",

language = "English (US)",

volume = "7",

pages = "15--34",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1

AU - Mayeux, Richard

AU - Reitz, Christiane

AU - Brickman, Adam M.

AU - Haan, Mary N.

AU - Manly, Jennifer J.

AU - Glymour, M. Maria

AU - Weiss, Christopher C.

AU - Yaffe, Kristine

AU - Middleton, Laura

AU - Hendrie, Hugh C.

AU - Warren, Lauren H.

AU - Hayden, Kathleen M.

AU - Welsh-Bohmer, Kathleen A.

AU - Breitner, John C.S.

AU - Morris, John C.

N1 - Funding Information: This combined effort was supported by National Institute on Aging grants P01AG007232, R01AG012975, R01AG016206, R01AG009956, R01AG011380, P30AG028377, P50AG05681, and K01AG029336 .

PY - 2011/1

Y1 - 2011/1

N2 - In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia".

AB - In this article, the challenges faced by several noted population studies for Alzheimer dementia in operationalizing current clinical diagnostic criteria for Alzheimer's disease (AD) have been reviewed. Differences in case ascertainment, methodological biases, cultural and educational influences on test performance, inclusion of special populations such as underrepresented minorities and the oldest old, and detection of the earliest symptomatic stages of underlying AD have been considered. Classification of Alzheimer dementia may be improved by the incorporation of biomarkers for AD if the sensitivity, specificity, and predictive value of the biomarkers are established and if they are appropriate for epidemiological studies, as may occur should a plasma biomarker be developed. Biomarkers for AD could also facilitate studies of the interactions of various forms of neurodegenerative disorders with cerebrovascular disease, resulting in "mixed dementia".

KW - Alzheimer's disease

KW - Cognitive impairment

KW - Dementia

KW - Diagnostic criteria

UR - http://www.scopus.com/inward/record.url?scp=78751668879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751668879&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2010.11.005

DO - 10.1016/j.jalz.2010.11.005

M3 - Article

C2 - 21255741

AN - SCOPUS:78751668879

SN - 1552-5260

VL - 7

SP - 15

EP - 34

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 1

ER -

Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment - Part 1

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this