Opening the door to mitochondrial protein import

Robert E. Jensen, Arthur E. Johnson

Research output: Contribution to journalShort surveypeer-review

Abstract

After reconstitution into liposomes, Tim23p, a mitochondrial inner membrane protein required for protein import, forms an aqueous pore that is activated by a transmembrane potential and mitochondrial targeting peptides. A report in this issue suggests that proteins are translocated into the mitochondrial matrix through a channel formed by Tim23p. These data also suggest a mechanism by which protein import can occur without disrupting the permeablility barrier of the inner membrane.

Original languageEnglish (US)
Pages (from-to)1008-1010
Number of pages3
JournalNature Structural Biology
Volume8
Issue number12
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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