Open muscle biopsy in suspected myopathy

Diagnostic yield and clinical utility

Research output: Contribution to journalArticle

Abstract

Background: The purpose of the study was to investigate the diagnostic yield and clinical utility of open muscle biopsy and to identify pre-biopsy factors that might predict useful clinical results for suspected myopathy. Methods: Two-hundred fifty-eight muscle biopsies, performed for investigation of suspected myopathy, were evaluated. Results: A specific clinical diagnosis following muscle biopsy was made in 43% of cases. As a result of the biopsy, clinical diagnosis was changed in 47% and treatment was changed in 33% of cases. Results either led to a specific clinical diagnosis or changed the diagnosis/treatment in 74% of patients. Positive family history of myopathy and findings of myopathic irritability on electromyography had a negative predictive value for diagnosis change. Conclusions: Open muscle biopsy is useful in myopathy evaluation in the modern genetic era.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalEuropean Journal of Neurology
Volume17
Issue number1
DOIs
StatePublished - Jan 2010

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Muscular Diseases
Biopsy
Muscles
Electromyography
Therapeutics

Keywords

  • Diagnostic yield
  • Muscle biopsy
  • Myopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Open muscle biopsy in suspected myopathy : Diagnostic yield and clinical utility. / Lai, C. H.; Melli, G.; Chang, Y. J.; Skolasky, Richard; Corse, Andrea Markl; Wagner, Kathryn Rae; Cornblath, David.

In: European Journal of Neurology, Vol. 17, No. 1, 01.2010, p. 136-142.

Research output: Contribution to journalArticle

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