Open-loop and closed-loop optokinetic nystagmus (OKN) in myasthenia gravis and nonmyasthenic subjects

Qing Yang, Min Wei, Fuchuan Sun, Jing Tian, Xiangjun Chen, Chuanzhen Lu

Research output: Contribution to journalArticlepeer-review

Abstract

Optokinetic nystagmus (OKN) eye movements of myasthenia gravis (MG) and nonmyasthenic ocular palsies, and normal subjects were examined under closed-loop and open-loop conditions. The open-loop OKN condition was achieved by adding the signal of eye-movement velocity of OKN to the computer-generated signal controlling the stimulus grating moving. The OKN was recorded by means of electromagnetic search scleral coil technique. In MG patients, the open-loop gains of OKN increased significantly after the intramuscular injection of an acetylcholinesterase inhibitor, neostigmine, while the closed-loop OKN gains were not significantly changed. Both the closed-loop and open-loop OKN gains of normal subjects and nonmyasthenic patients were not increased for the administration of neostigmine. The experimental results indicated that the open-loop OKN gain could be sensitive to reflect the changes of the function of neuromuscular junction in MG patients. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)166-172
Number of pages7
JournalExperimental Neurology
Volume166
Issue number1
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Myasthenia gravis
  • Neostigmine
  • OKN gain
  • Ocular motor
  • Open-loop control
  • Optokinetic nystagmus

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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