Abstract
Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.
Original language | English (US) |
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Pages (from-to) | 2320-2322 |
Number of pages | 3 |
Journal | Neurology |
Volume | 62 |
Issue number | 12 |
State | Published - Jun 22 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- General Neuroscience