Open-label dose-escalation on study of oral 1-octanol in patients with essential tremor

H. A. Shill; K. O. Bushara; Z. Mari; M. Reich; M. Hallett

Open-label dose-escalation on study of oral 1-octanol in patients with essential tremor

H. A. Shill, K. O. Bushara, Z. Mari, M. Reich, M. Hallett

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.

Original language	English (US)
Pages (from-to)	2320-2322
Number of pages	3
Journal	Neurology
Volume	62
Issue number	12
State	Published - Jun 22 2004
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

Cite this

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abstract = "Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.",

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AU - Shill, H. A.

AU - Bushara, K. O.

AU - Mari, Z.

AU - Reich, M.

AU - Hallett, M.

PY - 2004/6/22

Y1 - 2004/6/22

N2 - Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.

AB - Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.

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JO - Neurology

JF - Neurology

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ER -

Open-label dose-escalation on study of oral 1-octanol in patients with essential tremor

Abstract

ASJC Scopus subject areas

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