Oocyte maturation failure: A syndrome of bad eggs

Stephanie Beall, Carol Brenner, James Segars

Research output: Contribution to journalArticlepeer-review


To show that disruption of meiotic competence results in cell cycle arrest, and the production of immature oocytes that are not capable of fertilization. Through an extensive review of animal studies and clinical case reports, we define the syndrome of oocyte maturation failure as a distinct oocyte disorder, present a classification system based on clinical parameters, and discuss the potential molecular origins for the disease.

Original languageEnglish (US)
Pages (from-to)2507-2513
Number of pages7
JournalFertility and sterility
Issue number7
StatePublished - Dec 2010
Externally publishedYes


  • Oocyte maturation
  • meiotic arrest
  • oocyte arrest
  • sterility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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