Ontological labels for automated location of anatomical shape differences

Shane Steinert-Threlkeld, Siamak Ardekani, Jose L.V. Mejino, Landon Todd Detwiler, James F. Brinkley, Michael Halle, Ron Kikinis, Raimond L. Winslow, Michael I. Miller, J. Tilak Ratnanather

Research output: Contribution to journalArticle

Abstract

A method for automated location of shape differences in diseased anatomical structures via high resolution biomedical atlases annotated with labels from formal ontologies is described. In particular, a high resolution magnetic resonance image of the myocardium of the human left ventricle was segmented and annotated with structural terms from an extracted subset of the Foundational Model of Anatomy ontology. The atlas was registered to the end systole template of a previous study of left ventricular remodeling in cardiomyopathy using a diffeomorphic registration algorithm. The previous study used thresholding and visual inspection to locate a region of statistical significance which distinguished patients with ischemic cardiomyopathy from those with nonischemic cardiomyopathy. Using semantic technologies and the deformed annotated atlas, this location was more precisely found. Although this study used only a cardiac atlas, it provides a proof-of-concept that ontologically labeled biomedical atlases of any anatomical structure can be used to automate location-based inferences.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalJournal of Biomedical Informatics
Volume45
Issue number3
DOIs
StatePublished - Jun 1 2012

Keywords

  • Cardiac left ventricle
  • Computational anatomy
  • Medical atlases
  • Ontologies

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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    Steinert-Threlkeld, S., Ardekani, S., Mejino, J. L. V., Detwiler, L. T., Brinkley, J. F., Halle, M., Kikinis, R., Winslow, R. L., Miller, M. I., & Ratnanather, J. T. (2012). Ontological labels for automated location of anatomical shape differences. Journal of Biomedical Informatics, 45(3), 522-527. https://doi.org/10.1016/j.jbi.2012.02.013