Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas

R. J. D'Amato; Mary E Blue; B. L. Largent; D. R. Lynch; D. J. Ledbetter; M. E. Molliver; S. H. Snyder

doi:10.1073/pnas.84.12.4322

Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas

R. J. D'Amato, Mary E Blue, B. L. Largent, D. R. Lynch, D. J. Ledbetter, M. E. Molliver, S. H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

242 Scopus citations

Abstract

The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transient physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.

Original language	English (US)
Pages (from-to)	4322-4326
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	84
Issue number	12
DOIs	https://doi.org/10.1073/pnas.84.12.4322
State	Published - 1987

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.84.12.4322

Cite this

D'Amato, R. J., Blue, M. E., Largent, B. L., Lynch, D. R., Ledbetter, D. J., Molliver, M. E., & Snyder, S. H. (1987). Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas. Proceedings of the National Academy of Sciences of the United States of America, 84(12), 4322-4326. https://doi.org/10.1073/pnas.84.12.4322

Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas. / D'Amato, R. J.; Blue, Mary E; Largent, B. L. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 12, 1987, p. 4322-4326.

Research output: Contribution to journal › Article › peer-review

D'Amato, RJ, Blue, ME, Largent, BL, Lynch, DR, Ledbetter, DJ, Molliver, ME & Snyder, SH 1987, 'Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas', Proceedings of the National Academy of Sciences of the United States of America, vol. 84, no. 12, pp. 4322-4326. https://doi.org/10.1073/pnas.84.12.4322

@article{38c75d4356c046c8893a1380b7af2598,

title = "Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas",

abstract = "The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transient physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.",

author = "D'Amato, {R. J.} and Blue, {Mary E} and Largent, {B. L.} and Lynch, {D. R.} and Ledbetter, {D. J.} and Molliver, {M. E.} and Snyder, {S. H.}",

year = "1987",

doi = "10.1073/pnas.84.12.4322",

language = "English (US)",

volume = "84",

pages = "4322--4326",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "12",

}

TY - JOUR

T1 - Ontogeny of the serotonergic projection to rat neocortex

T2 - Transient expression of a dense innervation to primary sensory areas

AU - D'Amato, R. J.

AU - Blue, Mary E

AU - Largent, B. L.

AU - Lynch, D. R.

AU - Ledbetter, D. J.

AU - Molliver, M. E.

AU - Snyder, S. H.

PY - 1987

Y1 - 1987

N2 - The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transient physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.

AB - The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatosensory cortex, dense patches of serotonergic innervation are aligned with specialized cellular aggregates called barrels. The dense patches are not apparent after 3 weeks of age, and the serotonergic innervation becomes more uniform in adult neocortex. This precocious neonatal serotonergic innervation may play a transient physiologic role in sensory areas of cortex or may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.

UR - http://www.scopus.com/inward/record.url?scp=0023235290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023235290&partnerID=8YFLogxK

U2 - 10.1073/pnas.84.12.4322

DO - 10.1073/pnas.84.12.4322

M3 - Article

C2 - 3473503

AN - SCOPUS:0023235290

SN - 0027-8424

VL - 84

SP - 4322

EP - 4326

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 12

ER -

Ontogeny of the serotonergic projection to rat neocortex: Transient expression of a dense innervation to primary sensory areas

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this