TY - JOUR
T1 - Ontogeny of the Dyad
T2 - the Relationship Between Maternal and Offspring Neuroendocrine Function
AU - Voegtline, Kristin M.
AU - Dhaurali, Supriya
AU - Wainger, Julia
AU - Lauzon, Sylvie
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/5
Y1 - 2022/5
N2 - Purpose of Review: We review ontogeny of the maternal-offspring neuroendocrine relationship in human pregnancy. We present bidirectional genetic, physiological, and behavioral influences that enhance or disrupt HPA activity and its end product cortisol at the individual level and within the dyad. Recent Findings: Consistent evidence supports that maternal mood and caregiving behavior are associated with maternal and offspring cortisol levels. Select studies support the buffering effects of antidepressant use and maternal positive affect on offspring cortisol. Growing research highlights evocative effects of fetal neuroendocrine activity, antenatal gene transfer, and infant behavioral distress and risk characteristics on maternal cortisol levels and dyadic attunement. Summary: There is potential to advance our understanding of the mother–offspring neuroendocrine relationship by consideration of other neuroactive steroids in addition to cortisol, and to consider developmental timing and measurement source in study design. Future study should emphasize in what context or for whom neuroendocrine attunement is adaptive versus maladaptive for mother and child.
AB - Purpose of Review: We review ontogeny of the maternal-offspring neuroendocrine relationship in human pregnancy. We present bidirectional genetic, physiological, and behavioral influences that enhance or disrupt HPA activity and its end product cortisol at the individual level and within the dyad. Recent Findings: Consistent evidence supports that maternal mood and caregiving behavior are associated with maternal and offspring cortisol levels. Select studies support the buffering effects of antidepressant use and maternal positive affect on offspring cortisol. Growing research highlights evocative effects of fetal neuroendocrine activity, antenatal gene transfer, and infant behavioral distress and risk characteristics on maternal cortisol levels and dyadic attunement. Summary: There is potential to advance our understanding of the mother–offspring neuroendocrine relationship by consideration of other neuroactive steroids in addition to cortisol, and to consider developmental timing and measurement source in study design. Future study should emphasize in what context or for whom neuroendocrine attunement is adaptive versus maladaptive for mother and child.
KW - Bidirectional relationship
KW - Cortisol
KW - Maternal–fetal
KW - Mother-infant
KW - Neuroendocrine attunement
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U2 - 10.1007/s11920-022-01337-0
DO - 10.1007/s11920-022-01337-0
M3 - Review article
C2 - 35451797
AN - SCOPUS:85128755146
SN - 1523-3812
VL - 24
SP - 297
EP - 306
JO - Current psychiatry reports
JF - Current psychiatry reports
IS - 5
ER -