Ontogeny of sigma opiate/phencyclidine-binding sites in rat brain

Ratna Sircar, Stephen R. Zukin

Research output: Contribution to journalArticlepeer-review


The development of stereospecific sigma opiate/phencyclidine (PCP)-binding sites in fetal and neonatal rat brain was examined. Displaceable PCP binding was detected from day 13 of gestation. Bmax values increased to adult levels just prior to birth. Apparent KD values did not change. Stereospecific binding became detectable after day 19, concomitant with a rapid increase in Bmax. Despite the early appearance of binding, pharmacologically relevant stereospecific sigma opiate/PCP-binding sites do not become evident until shortly prior to parturition.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalLife Sciences
Issue numberSUPPL. 1
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology


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