Ontogeny of sigma opiate/phencyclidine-binding sites in rat brain

Ratna Sircar, Stephen R. Zukin

Research output: Contribution to journalArticle

Abstract

The development of stereospecific sigma opiate/phencyclidine (PCP)-binding sites in fetal and neonatal rat brain was examined. Displaceable PCP binding was detected from day 13 of gestation. Bmax values increased to adult levels just prior to birth. Apparent KD values did not change. Stereospecific binding became detectable after day 19, concomitant with a rapid increase in Bmax. Despite the early appearance of binding, pharmacologically relevant stereospecific sigma opiate/PCP-binding sites do not become evident until shortly prior to parturition.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalLife Sciences
Volume33
Issue numberSUPPL. 1
DOIs
StatePublished - 1983
Externally publishedYes

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Opiate Alkaloids
Phencyclidine
Rats
Brain
Binding Sites
Parturition
Pregnancy

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ontogeny of sigma opiate/phencyclidine-binding sites in rat brain. / Sircar, Ratna; Zukin, Stephen R.

In: Life Sciences, Vol. 33, No. SUPPL. 1, 1983, p. 255-258.

Research output: Contribution to journalArticle

Sircar, Ratna ; Zukin, Stephen R. / Ontogeny of sigma opiate/phencyclidine-binding sites in rat brain. In: Life Sciences. 1983 ; Vol. 33, No. SUPPL. 1. pp. 255-258.
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