Ontogeny of renin and AT1 receptor in the rat

R. Ariel Gomez, Alda Tufro-McReddie, Allen D. Everett, Ellen S. Pentz

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The enzyme renin and the angiotensin II (Ang II), subtype I receptor (ATI) are developmentally regulated in a tissue-specific manner. In early life, renin is expressed widely along the renal vasculature. As maturation progresses, there is a decrease in renin mRNA levels and a shift in the localization of renin close to the glomerulus. In addition, in the newborn rat, the number of renin-secreting cells is higher than in the adult rat. Exposure of neonatal and adult cells to Ang II results in a decrease of similar magnitude in the number of renin-secreting cells. These findings suggest that the high levels of renin observed in immature animals are due to increased renin synthesis and release rather than to a blunted response to Ang II. Expression of the ATI gene is also developmentally regulated in a tissue-specific manner. With maturation, ATI mRNA levels decrease in the kidney while they increase in the liver. The localization of ATI transcripts in precursor cells of the nephrogenic cortex suggests a role for this receptor in nephron growth and development. Inhibition of ATI with DUP753 results in delayed kidney and somatic growth and in increased renin mRNA levels and recruitment of renin-containing cells. These observations suggest that Ang II exerts a tonic negative feedback on renin gene expression via the ATI receptor subtype. Further studies are necessary to delineate the molecular and cellular signals mediating these developmental changes.

Original languageEnglish (US)
Pages (from-to)635-638
Number of pages4
JournalPediatric Nephrology
Issue number5
StatePublished - Oct 1 1993
Externally publishedYes


  • In situ hybridization
  • Kidney development
  • Messenger ribonucleic acid
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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