Ontogeny of dopamine transporter mRNA expression in the rat brain

Masahiro Fujita; Shoichi Shimada; Tsunehiko Nishimura; George R. Uhl; Masaya Tohyama

doi:10.1016/0169-328X(93)90031-J

Ontogeny of dopamine transporter mRNA expression in the rat brain

Masahiro Fujita, Shoichi Shimada, Tsunehiko Nishimura, George R. Uhl, Masaya Tohyama

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The ontogeny of dopamine transporter (DAT) gene expression was studied in the rat brain. DAT mRNA was first detected in neurons of the ventrocaudal mesencephalon on embryonic day 14 (E14). By E18, intensely expressing neurons in the ventral tegmental area and substantia nigra resembled the pattern found in adult midbrain. DAT mRNA is not abundant in the hypothalamus and the olfactory bulb at any stage of development. These results parallel those noted for tyrosine hydroxylase gene expression in mesencephalon.

Original language	English (US)
Pages (from-to)	222-226
Number of pages	5
Journal	Molecular Brain Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0169-328X(93)90031-J
State	Published - 1993

Keywords

Dopamine transporter
In situ hybridization histochemistry
Ontogeny
Substantia nigra
Ventral tegmental area

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(93)90031-J

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title = "Ontogeny of dopamine transporter mRNA expression in the rat brain",

abstract = "The ontogeny of dopamine transporter (DAT) gene expression was studied in the rat brain. DAT mRNA was first detected in neurons of the ventrocaudal mesencephalon on embryonic day 14 (E14). By E18, intensely expressing neurons in the ventral tegmental area and substantia nigra resembled the pattern found in adult midbrain. DAT mRNA is not abundant in the hypothalamus and the olfactory bulb at any stage of development. These results parallel those noted for tyrosine hydroxylase gene expression in mesencephalon.",

keywords = "Dopamine transporter, In situ hybridization histochemistry, Ontogeny, Substantia nigra, Ventral tegmental area",

author = "Masahiro Fujita and Shoichi Shimada and Tsunehiko Nishimura and Uhl, {George R.} and Masaya Tohyama",

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AU - Shimada, Shoichi

AU - Nishimura, Tsunehiko

AU - Uhl, George R.

AU - Tohyama, Masaya

PY - 1993

Y1 - 1993

N2 - The ontogeny of dopamine transporter (DAT) gene expression was studied in the rat brain. DAT mRNA was first detected in neurons of the ventrocaudal mesencephalon on embryonic day 14 (E14). By E18, intensely expressing neurons in the ventral tegmental area and substantia nigra resembled the pattern found in adult midbrain. DAT mRNA is not abundant in the hypothalamus and the olfactory bulb at any stage of development. These results parallel those noted for tyrosine hydroxylase gene expression in mesencephalon.

AB - The ontogeny of dopamine transporter (DAT) gene expression was studied in the rat brain. DAT mRNA was first detected in neurons of the ventrocaudal mesencephalon on embryonic day 14 (E14). By E18, intensely expressing neurons in the ventral tegmental area and substantia nigra resembled the pattern found in adult midbrain. DAT mRNA is not abundant in the hypothalamus and the olfactory bulb at any stage of development. These results parallel those noted for tyrosine hydroxylase gene expression in mesencephalon.

KW - Dopamine transporter

KW - In situ hybridization histochemistry

KW - Ontogeny

KW - Substantia nigra

KW - Ventral tegmental area

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Ontogeny of dopamine transporter mRNA expression in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

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