Ontogeny of dopamine daily rhythms within rabbit brainstem regions

Jeannine L. Gingras, Edward Lawson, M. C. McNamara

Research output: Contribution to journalArticle

Abstract

To examine the development of daily variations in dopamine levels, we measured dopamine concentrations within five distinct brainstem regions in 3- and 21-day-old, and adult rabbits at 09.30, 15.30, 21.30 and 03.30 h. Dopamine was measured by radioenzymatic assay and the dopamine concentration was expressed relative to wet tissue weight. In addition to defining the presence of a daily variation in the dopamine concentration in the whole brainstem, we were interested in identifying brainstem region-specific differences in this daily variation. Our data suggest that daily variations in dopamine concentrations are established by 3 days of life. Analysis of gross brainstem daily variation data suggest a peak in the dopamine concentration during the early light phase (09.30 h) for 3-day-old animals in contrast to a late light phase peak (15.30 h) for 21-day-old animals. Adult animals showed a peak in the early dark phase (21.30 h). These gross daily variations reflect the net sum of distinct region-specific patterns in the dopamine concentration. Analysis by region reflects a region-specific ontogeny in the development of daily variations for dopamine. Dopamine is involved in cardiorespiratory regulation. The observed developmental patterns may relate to the maturation and integration of these physiologic processes.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalNeonatology
Volume67
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Brain Stem
Dopamine
Rabbits
Light
Weights and Measures

Keywords

  • Brain development
  • Brainstem
  • Catecholamine
  • Circadian rhythms
  • Colliculi
  • Dopamine
  • Medulla
  • Neurotransmitter
  • Pons
  • Respiratory control

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Ontogeny of dopamine daily rhythms within rabbit brainstem regions. / Gingras, Jeannine L.; Lawson, Edward; McNamara, M. C.

In: Neonatology, Vol. 67, No. 4, 1995, p. 287-294.

Research output: Contribution to journalArticle

Gingras, Jeannine L. ; Lawson, Edward ; McNamara, M. C. / Ontogeny of dopamine daily rhythms within rabbit brainstem regions. In: Neonatology. 1995 ; Vol. 67, No. 4. pp. 287-294.
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