Ontogenic variation in acute lethality of cadmium in C57BL/6J mice

David J. Thomas, Richard A. Winchurch, P. C. Huang

Research output: Contribution to journalArticle

Abstract

Susceptibility of C57BL/6J mice to the lethal effects of parenterally administered Cd declined as a function of age at exposure. The 7-day LD50 increased from 1.65 mg Cd/kg body wt in 7-day-old mice to 4.08 mg/kg in adult mice. Survival time following treatment with Cd also increased as a function of age. High constitutive concentrations of metallothionein, a transition metal-binding protein, in livers of young mice did not protect against the lethality of Cd. These results suggest that, in the mouse, the interaction between Cd and this metal-binding protein may be affected by age at exposure to this toxic metal.

Original languageEnglish (US)
Pages (from-to)317-323
Number of pages7
JournalToxicology
Volume47
Issue number3
DOIs
StatePublished - Dec 14 1987

Keywords

  • Cadmium
  • Lethality
  • Metallothionein
  • Mice
  • Neonatal

ASJC Scopus subject areas

  • Toxicology

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