Ontogenetic Development of Histamine H1‐ Receptor Binding in Rat Brain

Vinh Tan Tran, Andrew D. Freeman, Raymond S.L. Chang, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review


Abstract: Histamine H1‐ receptors labeled with [3H]mepyramine in rat brain show an age‐dependent development. [3H]Mepyramine receptor density and histidine decarboxylase activity in whole rat brain reach adult levels at 25–30 days after birth and they attain 50% of adult level at day 10 and 17, respectively. The apparently later development of histidine decarboxylase activity in whole rat brain is partly accounted for by a biphasic developmental increase of this enzymatic activity in cerebral cortex. For all other brain regions examined, the development of histamine H1‐ receptors parallels that of histidine decarboxylase. The increase in [3H]mepyramine binding can be accounted for by an absolute increase in the numbers of the receptor sites, with no change in affinity. Subcellular fractionation studies indicate that histamine H1‐ receptors are predominantly associated with synaptosomal fractions derived from both newborn and adult rat.

Original languageEnglish (US)
Pages (from-to)1609-1613
Number of pages5
JournalJournal of Neurochemistry
Issue number6
StatePublished - Jun 1980


  • Histamine H receptor
  • Histidine decarboxylase
  • Ontogenesis
  • Subcellular distribution

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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