Ontogenetic development of histamine H1-receptor binding in rat brain

V. T. Tran, A. D. Freeman, R. S L Chang, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Histamine H1-receptors labeled with [3H]mepyramine in rat brain show an age-dependent development. [3H]Mepyramine receptor density and histidine decarboxylase activity in whole rat brain reach adult levels at 25-30 days after birth and they attain 50% of adult level at day 10 and 17, respectively. The apparently later development of histidine decarboxylase activity in whole rat brain is partly accounted for by a biphasic developmental increase of this enzymatic activity in cerebral cortex. For all other brain regions examined, the development of histamine H1-receptors parallels that of histidine decarboxylase. The increase in [3H]mepyramine binding can be accounted for by an absolute increase in the numbers of the receptor sites, with no change in affinity. Subcellular fractionation studies indicate that histamine H1-receptors are predominantly associated with synaptosomal fractions derived from both newborn and adult rat.

Original languageEnglish (US)
Pages (from-to)1609-1613
Number of pages5
JournalJournal of Neurochemistry
Volume34
Issue number6
StatePublished - 1980

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Histamine H1 Receptors
Histidine Decarboxylase
Pyrilamine
Rats
Brain
Fractionation
Cerebral Cortex
Parturition

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Tran, V. T., Freeman, A. D., Chang, R. S. L., & Snyder, S. H. (1980). Ontogenetic development of histamine H1-receptor binding in rat brain. Journal of Neurochemistry, 34(6), 1609-1613.

Ontogenetic development of histamine H1-receptor binding in rat brain. / Tran, V. T.; Freeman, A. D.; Chang, R. S L; Snyder, Solomon H.

In: Journal of Neurochemistry, Vol. 34, No. 6, 1980, p. 1609-1613.

Research output: Contribution to journalArticle

Tran, VT, Freeman, AD, Chang, RSL & Snyder, SH 1980, 'Ontogenetic development of histamine H1-receptor binding in rat brain', Journal of Neurochemistry, vol. 34, no. 6, pp. 1609-1613.
Tran, V. T. ; Freeman, A. D. ; Chang, R. S L ; Snyder, Solomon H. / Ontogenetic development of histamine H1-receptor binding in rat brain. In: Journal of Neurochemistry. 1980 ; Vol. 34, No. 6. pp. 1609-1613.
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