One-year cognitive and neurologic outcomes in survivors of paediatric extracorporeal cardiopulmonary resuscitation

for the Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss

Research output: Contribution to journalArticle

Abstract

Objective: To describe one-year cognitive and neurologic outcomes among extracorporeal cardiopulmonary resuscitation (ECPR) survivors enrolled in the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial; and compare outcomes between survivors who received ECPR, later extracorporeal membrane oxygenation (ECMO), or no ECMO. Methods: All children recruited to THAPCA-IH were comatose post-arrest. Neurobehavioral function was assessed by caregivers using the Vineland Adaptive Behaviour Scales, 2nd edition (VABS-II) at pre-arrest baseline and 12 months post-arrest. Age-appropriate cognitive performance measures (Mullen Scales of Early Learning or Wechsler Abbreviated Scale of Intelligence) and neurologic examinations were obtained 12 months post-arrest. VABS-II and cognitive performance measures were transformed to standard scores (mean = 100, SD = 15) with higher scores representing better performance. Only children with broadly normal pre-arrest function (VABS-II >70) were included in this analysis. Results: One-year follow-up was attained for 127 survivors with pre-arrest VABS-II >70. Of these, 57 received ECPR, 14 received ECMO later in their course, and 56 did not receive ECMO. VABS-II assessments were completed at 12 months for 55 (96.5%) ECPR survivors, cognitive testing for 44 (77.2%) and neurologic examination for 47 (82.5%). At 12 months, 39 (70.9%) ECPR survivors had VABS-II scores >70. On cognitive testing, 24 (54.6%) had scores >70, and on neurologic examination, 28 (59.5%) had no/minimal to mild impairment. Cognitive and neurologic score distributions were similar between ECPR, later ECMO and no ECMO groups. Conclusions: Many ECPR survivors had favourable outcomes although impairments were common. ECPR survivors had similar outcomes to other survivors who were initially comatose post-arrest.

Original languageEnglish (US)
JournalResuscitation
DOIs
StatePublished - Jan 1 2019

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Cardiopulmonary Resuscitation
Extracorporeal Membrane Oxygenation
Nervous System
Survivors
Psychological Adaptation
Pediatrics
Neurologic Examination
Induced Hypothermia
Coma
Heart Arrest
Wechsler Scales
Only Child
Intelligence
Caregivers
Learning

Keywords

  • Cognitive
  • Extracorporeal cardiopulmonary resuscitation
  • Neurobehavioral
  • Neurologic
  • Outcome
  • Paediatric

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

One-year cognitive and neurologic outcomes in survivors of paediatric extracorporeal cardiopulmonary resuscitation. / for the Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss.

In: Resuscitation, 01.01.2019.

Research output: Contribution to journalArticle

for the Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss. / One-year cognitive and neurologic outcomes in survivors of paediatric extracorporeal cardiopulmonary resuscitation. In: Resuscitation. 2019.
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abstract = "Objective: To describe one-year cognitive and neurologic outcomes among extracorporeal cardiopulmonary resuscitation (ECPR) survivors enrolled in the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial; and compare outcomes between survivors who received ECPR, later extracorporeal membrane oxygenation (ECMO), or no ECMO. Methods: All children recruited to THAPCA-IH were comatose post-arrest. Neurobehavioral function was assessed by caregivers using the Vineland Adaptive Behaviour Scales, 2nd edition (VABS-II) at pre-arrest baseline and 12 months post-arrest. Age-appropriate cognitive performance measures (Mullen Scales of Early Learning or Wechsler Abbreviated Scale of Intelligence) and neurologic examinations were obtained 12 months post-arrest. VABS-II and cognitive performance measures were transformed to standard scores (mean = 100, SD = 15) with higher scores representing better performance. Only children with broadly normal pre-arrest function (VABS-II >70) were included in this analysis. Results: One-year follow-up was attained for 127 survivors with pre-arrest VABS-II >70. Of these, 57 received ECPR, 14 received ECMO later in their course, and 56 did not receive ECMO. VABS-II assessments were completed at 12 months for 55 (96.5{\%}) ECPR survivors, cognitive testing for 44 (77.2{\%}) and neurologic examination for 47 (82.5{\%}). At 12 months, 39 (70.9{\%}) ECPR survivors had VABS-II scores >70. On cognitive testing, 24 (54.6{\%}) had scores >70, and on neurologic examination, 28 (59.5{\%}) had no/minimal to mild impairment. Cognitive and neurologic score distributions were similar between ECPR, later ECMO and no ECMO groups. Conclusions: Many ECPR survivors had favourable outcomes although impairments were common. ECPR survivors had similar outcomes to other survivors who were initially comatose post-arrest.",
keywords = "Cognitive, Extracorporeal cardiopulmonary resuscitation, Neurobehavioral, Neurologic, Outcome, Paediatric",
author = "{for the Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss} and Kathleen Meert and Slomine, {Beth S} and Silverstein, {Faye S.} and Christensen, {James R} and Rebecca Ichord and Russell Telford and Richard Holubkov and Dean, {J. Michael} and Moler, {Frank W.}",
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AU - for the Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss

AU - Meert, Kathleen

AU - Slomine, Beth S

AU - Silverstein, Faye S.

AU - Christensen, James R

AU - Ichord, Rebecca

AU - Telford, Russell

AU - Holubkov, Richard

AU - Dean, J. Michael

AU - Moler, Frank W.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To describe one-year cognitive and neurologic outcomes among extracorporeal cardiopulmonary resuscitation (ECPR) survivors enrolled in the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial; and compare outcomes between survivors who received ECPR, later extracorporeal membrane oxygenation (ECMO), or no ECMO. Methods: All children recruited to THAPCA-IH were comatose post-arrest. Neurobehavioral function was assessed by caregivers using the Vineland Adaptive Behaviour Scales, 2nd edition (VABS-II) at pre-arrest baseline and 12 months post-arrest. Age-appropriate cognitive performance measures (Mullen Scales of Early Learning or Wechsler Abbreviated Scale of Intelligence) and neurologic examinations were obtained 12 months post-arrest. VABS-II and cognitive performance measures were transformed to standard scores (mean = 100, SD = 15) with higher scores representing better performance. Only children with broadly normal pre-arrest function (VABS-II >70) were included in this analysis. Results: One-year follow-up was attained for 127 survivors with pre-arrest VABS-II >70. Of these, 57 received ECPR, 14 received ECMO later in their course, and 56 did not receive ECMO. VABS-II assessments were completed at 12 months for 55 (96.5%) ECPR survivors, cognitive testing for 44 (77.2%) and neurologic examination for 47 (82.5%). At 12 months, 39 (70.9%) ECPR survivors had VABS-II scores >70. On cognitive testing, 24 (54.6%) had scores >70, and on neurologic examination, 28 (59.5%) had no/minimal to mild impairment. Cognitive and neurologic score distributions were similar between ECPR, later ECMO and no ECMO groups. Conclusions: Many ECPR survivors had favourable outcomes although impairments were common. ECPR survivors had similar outcomes to other survivors who were initially comatose post-arrest.

AB - Objective: To describe one-year cognitive and neurologic outcomes among extracorporeal cardiopulmonary resuscitation (ECPR) survivors enrolled in the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial; and compare outcomes between survivors who received ECPR, later extracorporeal membrane oxygenation (ECMO), or no ECMO. Methods: All children recruited to THAPCA-IH were comatose post-arrest. Neurobehavioral function was assessed by caregivers using the Vineland Adaptive Behaviour Scales, 2nd edition (VABS-II) at pre-arrest baseline and 12 months post-arrest. Age-appropriate cognitive performance measures (Mullen Scales of Early Learning or Wechsler Abbreviated Scale of Intelligence) and neurologic examinations were obtained 12 months post-arrest. VABS-II and cognitive performance measures were transformed to standard scores (mean = 100, SD = 15) with higher scores representing better performance. Only children with broadly normal pre-arrest function (VABS-II >70) were included in this analysis. Results: One-year follow-up was attained for 127 survivors with pre-arrest VABS-II >70. Of these, 57 received ECPR, 14 received ECMO later in their course, and 56 did not receive ECMO. VABS-II assessments were completed at 12 months for 55 (96.5%) ECPR survivors, cognitive testing for 44 (77.2%) and neurologic examination for 47 (82.5%). At 12 months, 39 (70.9%) ECPR survivors had VABS-II scores >70. On cognitive testing, 24 (54.6%) had scores >70, and on neurologic examination, 28 (59.5%) had no/minimal to mild impairment. Cognitive and neurologic score distributions were similar between ECPR, later ECMO and no ECMO groups. Conclusions: Many ECPR survivors had favourable outcomes although impairments were common. ECPR survivors had similar outcomes to other survivors who were initially comatose post-arrest.

KW - Cognitive

KW - Extracorporeal cardiopulmonary resuscitation

KW - Neurobehavioral

KW - Neurologic

KW - Outcome

KW - Paediatric

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