@article{2c9a281576cf40c6bbc8e0a0e922a563,
title = "One-year cognitive and neurologic outcomes in survivors of paediatric extracorporeal cardiopulmonary resuscitation",
abstract = "Objective: To describe one-year cognitive and neurologic outcomes among extracorporeal cardiopulmonary resuscitation (ECPR) survivors enrolled in the Therapeutic Hypothermia after Paediatric Cardiac Arrest In-Hospital (THAPCA-IH) trial; and compare outcomes between survivors who received ECPR, later extracorporeal membrane oxygenation (ECMO), or no ECMO. Methods: All children recruited to THAPCA-IH were comatose post-arrest. Neurobehavioral function was assessed by caregivers using the Vineland Adaptive Behaviour Scales, 2nd edition (VABS-II) at pre-arrest baseline and 12 months post-arrest. Age-appropriate cognitive performance measures (Mullen Scales of Early Learning or Wechsler Abbreviated Scale of Intelligence) and neurologic examinations were obtained 12 months post-arrest. VABS-II and cognitive performance measures were transformed to standard scores (mean = 100, SD = 15) with higher scores representing better performance. Only children with broadly normal pre-arrest function (VABS-II ≥70) were included in this analysis. Results: One-year follow-up was attained for 127 survivors with pre-arrest VABS-II ≥70. Of these, 57 received ECPR, 14 received ECMO later in their course, and 56 did not receive ECMO. VABS-II assessments were completed at 12 months for 55 (96.5%) ECPR survivors, cognitive testing for 44 (77.2%) and neurologic examination for 47 (82.5%). At 12 months, 39 (70.9%) ECPR survivors had VABS-II scores ≥70. On cognitive testing, 24 (54.6%) had scores ≥70, and on neurologic examination, 28 (59.5%) had no/minimal to mild impairment. Cognitive and neurologic score distributions were similar between ECPR, later ECMO and no ECMO groups. Conclusions: Many ECPR survivors had favourable outcomes although impairments were common. ECPR survivors had similar outcomes to other survivors who were initially comatose post-arrest.",
keywords = "Cognitive, Extracorporeal cardiopulmonary resuscitation, Neurobehavioral, Neurologic, Outcome, Paediatric",
author = "{for the Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigatorss} and Kathleen Meert and Slomine, {Beth S.} and Silverstein, {Faye S.} and James Christensen and Rebecca Ichord and Russell Telford and Richard Holubkov and Dean, {J. Michael} and Moler, {Frank W.}",
note = "Funding Information: Primary support for the conduct of the THAPCA-IH Trial was funding from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute, Bethesda, MD. HL094345 (FWM) and HL094339 (JMD). Additional support from the following federal planning grants contributed to the planning of the THAPCA Trials: NIH, Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD), Bethesda, MD. HD044955 (FWM) and HD050531 (FWM). In part support was obtained from the participation of the following research networks: Paediatric Emergency Care Applied Research Network (PECARN) from cooperative agreements U03MC00001, U03MC00003, U03MC00006, U03MC00007, and U03MC00008; and the Collaborative Paediatric Critical Care Research Network (CPCCRN) from cooperative agreements (U10HD500009, U10HD050096, U10HD049981, U10HD049945, U10HD049983, U10HD050012 and U01HD049934. At several centres (as indicated below), clinical research support was supplemented by the following grants or Cooperative Agreements: UL1 RR 024986, UL1 TR 000433, U54 HD087011, UL1TR000003, and P30HD040677. The National Emergency Medical Services for Children (EMSC) Data Analysis Resource Centre Demonstration grant U07MC09174 provided for educational study materials. Hypothermia after Paediatric Cardiac Arrest (THAPCA) trial investigators participated in this study: Frank W. Moler, MD, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor; Kathleen L. Meert, MD, Children's Hospital of Michigan, Detroit; Jamie S. Hutchinson, MD, Hospital for Sick Children, Toronto, Ontario, Canada; Christopher J. L. Newth, MD, Children's Hospital Los Angeles, Los Angeles, California; Kimberly S. Bennett, MD, MPH, Primary Children's Hospital, Salt Lake City, Utah; John T. Berger, MD, Children's National Medical Centre, Washington, DC; Alexis A. Topjian, MD, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Jose A. Pineda, MD, Washington University, St Louis, Missouri; Joshua D. Koch, MD, Children's Medical Centre Dallas, University of Texas Southwestern Medical School; Charles L. Schleien, MD, MBA, Morgan Stanley Children's Hospital–Columbia University Medical Centre, New York, New York; Heidi J. Dalton, MD, Phoenix Children's Hospital, Phoenix, Arizona; George Ofori-Amanfo, MB, ChB, Duke Children's Hospital, Durham, North Carolina; Denise M. Goodman, MD, Anne and Robert Lurie Children's Hospital of Chicago, Chicago, Illinois; Ericka L. Fink, MD, University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania; Patrick McQuillen, MD, University of California, San Francisco Benioff Children's Hospital; Jerry J. Zimmerman, MD, PhD, Seattle Children's Hospital, Seattle, Washington; Neal J. Thomas, MD, Penn State Children's Hospital, Hershey, Pennsylvania; Elise W. van der Jagt, MD, MPH, University of Rochester Medical Centre/Golisano Children's Hospital, Rochester, New York; Melissa B. Porter, MD, Kosair Charities Paediatric Clinical Research Unit, Department of Paediatrics, University of Louisville and the Kosair Children's Hospital, Louisville, Kentucky; Michael T. Meyer, MD, Medical College of Wisconsin, Milwaukee; Rick Harrison, MD, Mattel Children's Hospital UCLA (University of California, Los Angeles); Nga Pham, MD, Children's Healthcare of Atlanta, Atlanta, Georgia; Adam J. Schwarz, MD, Children's Hospital of Orange County, Orange, California; Jeffrey E. Nowak, MD, Children's Hospitals and Clinics of Minnesota, Minneapolis; Jeffrey Alten, MD, The Children's Hospital of Alabama, Birmingham; Derek S. Wheeler, MD, Cincinnati Children's Hospital, Cincinnati, Ohio; Utpal S. Bhalala, MD, Johns Hopkins Children's Centre, Baltimore, Maryland; Karen Lidsky, MD, Rainbow Babies and Children's Hospital, Cleveland, Ohio; Eric Lloyd, MD, Nationwide Children's Hospital, Columbus, Ohio; Mudit Mathur, MD, Loma Linda University Children's Hospital, Loma Linda, California; Samir Shah, MD, University of Tennessee Health Science Centre, Memphis; Theodore Wu, MD, University of Texas Health Sciences Centre at San Antonio; Andreas A. Theodorou, MD, Diamond Children's Medical Centre, Tucson, Arizona; Ronald C. Sanders Jr, MD, Arkansas Children's Hospital, Little Rock; Faye S. Silverstein, MD, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor; James R. Christensen, MD, and Beth S. Slomine, PhD, Outcome Centre, Kennedy Krieger Institute, and Johns Hopkins University, School of Medicine, Baltimore, Maryland; Victoria L. Pemberton, RNC, MS, National Heart, Lung, and Blood Institute, Bethesda, Maryland; and Brittan Browning, MS, RD, CCRC, Richard Holubkov, PhD, and J. Michael Dean, MD, MBA, Data Coordinating Centre, University of Utah, Salt Lake City. Funding Information: Primary support for the conduct of the THAPCA-IH Trial was funding from the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute, Bethesda, MD. HL094345 (FWM) and HL094339 (JMD). Additional support from the following federal planning grants contributed to the planning of the THAPCA Trials: NIH, Eunice Kennedy Shriver National Institute of Child Health and Development ( NICHD ), Bethesda, MD. HD044955 (FWM) and HD050531 (FWM). In part support was obtained from the participation of the following research networks: Paediatric Emergency Care Applied Research Network ( PECARN ) from cooperative agreements U03MC00001, U03MC00003, U03MC00006, U03MC00007, and U03MC00008; and the Collaborative Paediatric Critical Care Research Network ( CPCCRN ) from cooperative agreements (U10HD500009, U10HD050096, U10HD049981, U10HD049945, U10HD049983, U10HD050012 and U01HD049934. At several centres (as indicated below), clinical research support was supplemented by the following grants or Cooperative Agreements: UL1 RR 024986, UL1 TR 000433, U54 HD087011, UL1TR000003, and P30HD040677. The National Emergency Medical Services for Children ( EMSC ) Data Analysis Resource Centre Demonstration grant U07MC09174 provided for educational study materials. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",
year = "2019",
month = jun,
doi = "10.1016/j.resuscitation.2019.02.023",
language = "English (US)",
volume = "139",
pages = "299--307",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",
}