One size may not fit all: Anti-aging therapies and sarcopenia

Tyesha N. Burks, Ronald D. Cohn

Research output: Contribution to journalArticle

Abstract

Sarcopenia refers to age-related loss of muscle mass and function. Several age-related changes occur in skeletal muscle including a decrease in myofiber size and number and a diminished ability of satellite cells to activate and proliferate upon injury leading to impaired muscle remodeling. Although the molecular mechanisms underlying sarcopenia are unknown, it is tempting to hypothesize that interplay between biological and environmental factors cooperate in a positive feedback cycle contributing to the progression of sarcopenia. Indeed many essential biological mechanisms such as apoptosis and autophagy and critical signaling pathways involved in skeletal muscle homeostasis are altered during aging and have been linked to loss of muscle mass. Moreover, the environmental effects of the sedentary lifestyle of older people further promote and contribute the loss of muscle mass. There are currently no widely accepted therapeutic strategies to halt or reverse the progression of sarcopenia. Caloric restriction has been shown to be beneficial as a sarcopenia and aging antagonist. Such results have made the search for caloric restriction mimetics (CRM) a priority. However given the mechanisms of action, some of the currently investigated CRMs may not combat sarcopenia. Thus, sarcopenia may represent a unique phenotypic feature of aging that requires specific and individually tailored therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)1142-1153
Number of pages12
JournalAging
Volume3
Issue number12
StatePublished - Dec 2011

Fingerprint

Sarcopenia
Muscles
Caloric Restriction
Therapeutics
Skeletal Muscle
Sedentary Lifestyle
Aptitude
Critical Pathways
Autophagy
Biological Factors
Homeostasis
Apoptosis
Wounds and Injuries

Keywords

  • Anti-aging
  • Caloric restriction
  • Caloric restriction mimetics
  • Sarcopenia
  • Skeletal muscle
  • Therapy

ASJC Scopus subject areas

  • Aging
  • Cell Biology

Cite this

Burks, T. N., & Cohn, R. D. (2011). One size may not fit all: Anti-aging therapies and sarcopenia. Aging, 3(12), 1142-1153.

One size may not fit all : Anti-aging therapies and sarcopenia. / Burks, Tyesha N.; Cohn, Ronald D.

In: Aging, Vol. 3, No. 12, 12.2011, p. 1142-1153.

Research output: Contribution to journalArticle

Burks, TN & Cohn, RD 2011, 'One size may not fit all: Anti-aging therapies and sarcopenia', Aging, vol. 3, no. 12, pp. 1142-1153.
Burks TN, Cohn RD. One size may not fit all: Anti-aging therapies and sarcopenia. Aging. 2011 Dec;3(12):1142-1153.
Burks, Tyesha N. ; Cohn, Ronald D. / One size may not fit all : Anti-aging therapies and sarcopenia. In: Aging. 2011 ; Vol. 3, No. 12. pp. 1142-1153.
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