One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response

Geetha Kannan, Emese Prandovszky, Curtis B. Steinfeldt, Kristin L. Gressitt, Chun Xia Yang, Robert H. Yolken, Emily G. Severance, Lorraine Jones-Brando, Mikhail V. Pletnikov

Research output: Contribution to journalArticle

Abstract

We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1. min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalExperimental Parasitology
Volume145
Issue number1
DOIs
StatePublished - Oct 2014

Keywords

  • Animal models
  • Behavior
  • Cysts
  • Immune response
  • Inactivation
  • Toxoplasma

ASJC Scopus subject areas

  • Parasitology
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response'. Together they form a unique fingerprint.

  • Cite this