One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents

Lye Lin Lock, Yuguo Li, Xinpei Mao, Hanwei Chen, Verena Staedtke, Renyuan Bai, Wang Ma, Ran Lin, Yi Li, Guanshu Liu, Honggang Cui

Research output: Contribution to journalArticle

Abstract

Gadolinium (Gd)-based compounds and materials are the most commonly used magnetic resonance imaging (MRI) contrast agents in the clinic; however, safety concerns associated with their toxicities in the free ionic form have promoted the development of new generations of metal-free contrast agents. Here we report a supramolecular strategy to convert an FDA-approved anticancer drug, Pemetrexed (Pem), to a molecular hydrogelator with inherent chemical exchange saturation transfer (CEST) MRI signals. The rationally designed drug-peptide conjugate can spontaneously associate into filamentous assemblies under physiological conditions and consequently form theranostic supramolecular hydrogels for injectable delivery. We demonstrated that the local delivery and distribution of Pem-peptide nanofiber hydrogels can be directly assessed using CEST MRI in a mouse glioma model. Our work lays out the foundation for the development of drug-constructed theranostic supramolecular materials with an inherent CEST MRI signal that enables noninvasive monitoring of their in vivo distribution and drug release.

Original languageEnglish (US)
Pages (from-to)797-805
Number of pages9
JournalACS Nano
Volume11
Issue number1
DOIs
StatePublished - Jan 24 2017

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Adenofibroma
Guanine Nucleotides
Magnetic resonance
Imaging techniques
magnetic resonance
drugs
Alcuronium
Hydrogels
saturation
Traffic Accidents
Peptides
peptides
delivery
Carbocyclic Acids
Inborn Errors Amino Acid Metabolism
Antimony Potassium Tartrate
Anthralin
Acrodermatitis
Nanofibers
Atrophy

Keywords

  • anticancer drugs
  • CEST
  • molecular assembly
  • MRI
  • supramolecular nanofibers

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents. / Lock, Lye Lin; Li, Yuguo; Mao, Xinpei; Chen, Hanwei; Staedtke, Verena; Bai, Renyuan; Ma, Wang; Lin, Ran; Li, Yi; Liu, Guanshu; Cui, Honggang.

In: ACS Nano, Vol. 11, No. 1, 24.01.2017, p. 797-805.

Research output: Contribution to journalArticle

Lock, Lye Lin; Li, Yuguo; Mao, Xinpei; Chen, Hanwei; Staedtke, Verena; Bai, Renyuan; Ma, Wang; Lin, Ran; Li, Yi; Liu, Guanshu; Cui, Honggang / One-Component Supramolecular Filament Hydrogels as Theranostic Label-Free Magnetic Resonance Imaging Agents.

In: ACS Nano, Vol. 11, No. 1, 24.01.2017, p. 797-805.

Research output: Contribution to journalArticle

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