TY - JOUR
T1 - One Actor, Many Roles
T2 - Histopathologies Associated with APOL1 Genetic Variants
AU - Kopp, Jeffrey B.
AU - Rosenberg, Avi Z.
N1 - Funding Information:
From the *Kidney Diseases Branch, NIDDK, NIH, Bethesda; and †Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD. Supported in part by the Intramural Research Program, NIDDK, NIH via project ZO1 DK043308 (J.B.K.) and the National Kidney Foundation of the National Capital Area, Joseph M. Krainin, MD, Memorial Young Investigator Award (A.Z.R). The authors have no conflicts of interest to disclose. Reprints: Jeffrey B. Kopp, MD, 10 Center Dr., 3N116, NIH, Bethesda, MD 20892-1268 (e-mail: jbkopp@nih.gov). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Genetic variants in APOL1, encoding apolipoprotein L1, are major drivers of glomerular disease in peoples of sub-Saharan African descent. APOL1-associated primary glomerular diseases include focal segmental glomerulosclerosis, human immunodeficiency virus-associated nephropathies, and arterionephrosclerosis. Other conditions where APOL1 variants affect outcomes include membranous nephropathy, lupus nephritis, diabetic nephropathy, preeclampsia, and kidney transplant. In focal segmental glomerulosclerosis, APOL1 variants are associated with upregulation of RNA encoding chemokine C-X-C motif receptor 3 ligands and ubiquitin D; the significance of these findings remains unclear but may provide valuable insight into disease mechanisms.
AB - Genetic variants in APOL1, encoding apolipoprotein L1, are major drivers of glomerular disease in peoples of sub-Saharan African descent. APOL1-associated primary glomerular diseases include focal segmental glomerulosclerosis, human immunodeficiency virus-associated nephropathies, and arterionephrosclerosis. Other conditions where APOL1 variants affect outcomes include membranous nephropathy, lupus nephritis, diabetic nephropathy, preeclampsia, and kidney transplant. In focal segmental glomerulosclerosis, APOL1 variants are associated with upregulation of RNA encoding chemokine C-X-C motif receptor 3 ligands and ubiquitin D; the significance of these findings remains unclear but may provide valuable insight into disease mechanisms.
KW - APOL1
KW - arterionephrosclerosis
KW - collapsing glomerulopathy
KW - focal segmental glomerulosclerosis
KW - genetic
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U2 - 10.1097/PAP.0000000000000221
DO - 10.1097/PAP.0000000000000221
M3 - Review article
C2 - 30624253
AN - SCOPUS:85059964245
SN - 1072-4109
VL - 26
SP - 215
EP - 219
JO - Advances in anatomic pathology
JF - Advances in anatomic pathology
IS - 3
ER -