Oncologic diagnosis with 2-[fluorine-18]fluoro-2-deoxy-D-glucose imaging: Dual-head coincidence gamma camera versus positron emission tomographic scanner

Paul D. Shreve, Robert S. Steventon, Eric C. Deters, Paul V. Kison, Milton D. Gross, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

PURPOSE: To compare the performance of a dual-head single photon emission computed tomographic (SPECT) Anger camera operated in coincidence mode with that of a dedicated positron emission tomographic (PET) scanner in the imaging of cancer with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG). MATERIALS AND METHODS: Thirty-one patients with known or suspected malignant neoplasms underwent imaging with both methods, and the images were read blindly. Diagnostic performance on a lesion-by-lesion basis was compared with attenuation-corrected PET as the standard of reference. RESULTS: Of a total of 109 discrete lesions depicted at PET, 60 (relative sensitivity, 55%) were identified on the coincidence-mode images. Of the nodules or masses depicted at PET, 13 (93%) of 14 lung nodules or masses, 20 (65%) of 31 mediastinal lymph nodes, five (71%) of seven lesions in the neck, five (55%) of nine axillary lymph nodes, 11 (50%) of 22 bone metastases, and six (23%) of 26 abdominal tumor deposits were correctly identified on the coincidence gamma camera images. CONCLUSION: These preliminary findings indicate FDG imaging with a modified dual-detector gamma camera operating in coincidence mode can depict many of the lesions depicted with a PET scanner, particularly in the lungs. Sensitivity for lesions detected at dedicated FDG PET was poor in the abdomen and in all locations outside the lungs for tumor deposits generally less than 1.5 cm in short-axis diameter.

Original languageEnglish (US)
Pages (from-to)431-437
Number of pages7
JournalRadiology
Volume207
Issue number2
StatePublished - 1998
Externally publishedYes

Fingerprint

Gamma Cameras
Fluorine
Deoxyglucose
Head
Electrons
Lung
Neoplasms
Lymph Nodes
Anger
Photons
Abdomen
Neck
Neoplasm Metastasis
Bone and Bones

Keywords

  • Abdomen, neoplasms
  • Bone neoplasms, emission CT (ECT)
  • Fluorine
  • Head and neck neoplasms, emission CT (ECT)
  • Lung neoplasms, emission CT (ECT)
  • Lymphatic system, neoplasms
  • Neoplasms, emission CT (ECT)

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Shreve, P. D., Steventon, R. S., Deters, E. C., Kison, P. V., Gross, M. D., & Wahl, R. L. (1998). Oncologic diagnosis with 2-[fluorine-18]fluoro-2-deoxy-D-glucose imaging: Dual-head coincidence gamma camera versus positron emission tomographic scanner. Radiology, 207(2), 431-437.

Oncologic diagnosis with 2-[fluorine-18]fluoro-2-deoxy-D-glucose imaging : Dual-head coincidence gamma camera versus positron emission tomographic scanner. / Shreve, Paul D.; Steventon, Robert S.; Deters, Eric C.; Kison, Paul V.; Gross, Milton D.; Wahl, Richard L.

In: Radiology, Vol. 207, No. 2, 1998, p. 431-437.

Research output: Contribution to journalArticle

Shreve, PD, Steventon, RS, Deters, EC, Kison, PV, Gross, MD & Wahl, RL 1998, 'Oncologic diagnosis with 2-[fluorine-18]fluoro-2-deoxy-D-glucose imaging: Dual-head coincidence gamma camera versus positron emission tomographic scanner', Radiology, vol. 207, no. 2, pp. 431-437.
Shreve, Paul D. ; Steventon, Robert S. ; Deters, Eric C. ; Kison, Paul V. ; Gross, Milton D. ; Wahl, Richard L. / Oncologic diagnosis with 2-[fluorine-18]fluoro-2-deoxy-D-glucose imaging : Dual-head coincidence gamma camera versus positron emission tomographic scanner. In: Radiology. 1998 ; Vol. 207, No. 2. pp. 431-437.
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abstract = "PURPOSE: To compare the performance of a dual-head single photon emission computed tomographic (SPECT) Anger camera operated in coincidence mode with that of a dedicated positron emission tomographic (PET) scanner in the imaging of cancer with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG). MATERIALS AND METHODS: Thirty-one patients with known or suspected malignant neoplasms underwent imaging with both methods, and the images were read blindly. Diagnostic performance on a lesion-by-lesion basis was compared with attenuation-corrected PET as the standard of reference. RESULTS: Of a total of 109 discrete lesions depicted at PET, 60 (relative sensitivity, 55{\%}) were identified on the coincidence-mode images. Of the nodules or masses depicted at PET, 13 (93{\%}) of 14 lung nodules or masses, 20 (65{\%}) of 31 mediastinal lymph nodes, five (71{\%}) of seven lesions in the neck, five (55{\%}) of nine axillary lymph nodes, 11 (50{\%}) of 22 bone metastases, and six (23{\%}) of 26 abdominal tumor deposits were correctly identified on the coincidence gamma camera images. CONCLUSION: These preliminary findings indicate FDG imaging with a modified dual-detector gamma camera operating in coincidence mode can depict many of the lesions depicted with a PET scanner, particularly in the lungs. Sensitivity for lesions detected at dedicated FDG PET was poor in the abdomen and in all locations outside the lungs for tumor deposits generally less than 1.5 cm in short-axis diameter.",
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