Oncologic applications of diffusion-weighted MRI in the body

Research output: Contribution to journalReview article

Abstract

Diffusion-weighted MRI (DWI) allows the detection of malignancies in the abdomen and pelvis. Lesion detection and characterization using DWI largely depends on the increased cellularity of solid or cystic lesions compared with the surrounding tissue. This increased cellularity leads results in restricted diffusion as indicated by reduction in the apparent diffusion coefficient (ADC). Low pretreatment ADC values of several malignancies have been shown to be predictive of better outcome. DWI can assess response to systemic or regional treatment of cancer at a cellular level and will therefore detect successful treatment earlier than anatomical measures. In this review, we provide a brief technical overview of DWI, discuss quantitative image analysis approaches, and review studies which have used DWI for the purpose of detection and characterization of malignancies as well as the early prediction of treatment response.

Original languageEnglish (US)
Pages (from-to)257-279
Number of pages23
JournalJournal of Magnetic Resonance Imaging
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • biomarker
  • cancer
  • cancer detection
  • diffusion-weighted MRI
  • treatment monitoring

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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