Oncogenic alterations of metabolism

Chi V. Dang, Gregg L Semenza

Research output: Contribution to journalArticle

Abstract

Over seven decades ago, classical biochemical studies showed that tumors have altered metabolic profiles and display high rates of glucose uptake and glycolysis. Although these metabolic changes are not the fundamental defects that cause cancer, they might confer a common advantage on many different types of cancers, which allows the cells to survive and invade. Recent molecular studies have revealed that several of the multiple genetic alterations that cause tumor development directly affect glycolysis, the cellular response to hypoxia and the ability of tumor cells to recruit new blood vessels.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalTrends in Biochemical Sciences
Volume24
Issue number2
DOIs
StatePublished - Feb 1 1999

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Metabolism
Tumors
Glycolysis
Neoplasms
Blood vessels
Metabolome
Cells
Blood Vessels
Glucose
Defects

ASJC Scopus subject areas

  • Biochemistry

Cite this

Oncogenic alterations of metabolism. / Dang, Chi V.; Semenza, Gregg L.

In: Trends in Biochemical Sciences, Vol. 24, No. 2, 01.02.1999, p. 68-72.

Research output: Contribution to journalArticle

Dang, Chi V. ; Semenza, Gregg L. / Oncogenic alterations of metabolism. In: Trends in Biochemical Sciences. 1999 ; Vol. 24, No. 2. pp. 68-72.
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