Oncogenic alterations of metabolism

Chi V. Dang, Gregg L. Semenza

Research output: Contribution to journalReview article

Abstract

Over seven decades ago, classical biochemical studies showed that tumors have altered metabolic profiles and display high rates of glucose uptake and glycolysis. Although these metabolic changes are not the fundamental defects that cause cancer, they might confer a common advantage on many different types of cancers, which allows the cells to survive and invade. Recent molecular studies have revealed that several of the multiple genetic alterations that cause tumor development directly affect glycolysis, the cellular response to hypoxia and the ability of tumor cells to recruit new blood vessels.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalTrends in biochemical sciences
Volume24
Issue number2
DOIs
StatePublished - Feb 1 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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