Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

John D. Hayes, Albena T. Dinkova-Kostova

Research output: Contribution to journalShort survey

Abstract

In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif. In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

Original languageEnglish (US)
Pages (from-to)539-541
Number of pages3
JournalCancer Cell
Volume32
Issue number5
DOIs
StatePublished - Nov 13 2017
Externally publishedYes

Fingerprint

Oncogenes
Oncogene Proteins
Ligases
Ubiquitin
Genes
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival. / Hayes, John D.; Dinkova-Kostova, Albena T.

In: Cancer Cell, Vol. 32, No. 5, 13.11.2017, p. 539-541.

Research output: Contribution to journalShort survey

@article{d4a376ef91a342ba9c4a65aee27c7806,
title = "Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival",
abstract = "In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif. In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.",
author = "Hayes, {John D.} and Dinkova-Kostova, {Albena T.}",
year = "2017",
month = "11",
day = "13",
doi = "10.1016/j.ccell.2017.10.009",
language = "English (US)",
volume = "32",
pages = "539--541",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

AU - Hayes, John D.

AU - Dinkova-Kostova, Albena T.

PY - 2017/11/13

Y1 - 2017/11/13

N2 - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif. In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

AB - In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif. In this issue of Cancer Cell, Ge et al. show that overexpression of the oncoprotein iASPP in cancer cells provokes NRF2-mediated induction of cytoprotective genes, because it logjams the ubiquitin ligase substrate adaptor function of KEAP1 by virtue of the fact that it possesses a novel DLT-containing KEAP1-interaction motif.

UR - http://www.scopus.com/inward/record.url?scp=85033721839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033721839&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2017.10.009

DO - 10.1016/j.ccell.2017.10.009

M3 - Short survey

C2 - 29136497

AN - SCOPUS:85033721839

VL - 32

SP - 539

EP - 541

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 5

ER -