Oncogene expression in prostate cancer: Dunning R3327 rat dorsal prostatic adenocarcinoma system

D. B. Cooke, V. E. Quarmby, D. D. Mickey, J. T. Isaacs, F. S. French

Research output: Contribution to journalArticle

Abstract

Steady‐state levels of myc, fos, p53, sis, and neu mRNAs were measured in eight variants derived from the Dunning R3327 rat prostate adenocarcinoma and compared to levels in normal dorsal prostate. Expression of the myb and serbB oncogenes in the Dunning tumors was below the limits of detection. Myc, p53, and sis mRNA levels in all tumors were at or above control levels. Fos mRNA levels were below control levels in four of five anaplastic tumors and were above control levels in the remaining tumors. A comparison of mRNA levels along the two Dunning lineages revealed that increased expression of these oncogenes did not correlate with tumor progression.

Original languageEnglish (US)
Pages (from-to)263-272
Number of pages10
JournalThe Prostate
Volume13
Issue number4
DOIs
StatePublished - 1988

Keywords

  • fos
  • myc
  • neu
  • p53
  • sis

ASJC Scopus subject areas

  • Oncology
  • Urology

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